A Study of Potential Pharmacokinetic and Pharmacodynamic Interactions between Dextromethorphan/Quinidine and Memantine in Healthy Volunteers

被引：1
|
作者：
Laura E. Pope
Kerri A. Schoedel
Cynthia Bartlett
Edward M. Sellers
机构：
[1] Avanir Pharmaceuticals,Clinical Research
[2] Inc.,undefined
[3] INC Research — Toronto,undefined
[4] DL Global Partners Inc.,undefined
来源：
Clinical Drug Investigation | 2012年 / 32卷 / 8期
关键词：
Quinidine; Memantine; Dextromethorphan; Beck Anxiety Inventory; Dextrorphan;
D O I：
10.1007/BF03261905
中图分类号：
学科分类号：
摘要：
Background and Objective: Dextromethorphan/quinidine (DMQ) is the first agent indicated for the treatment of pseudobulbar affect. Dextromethorphan, the active ingredient, is a low-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. This study evaluated the potential for a drug-drug interaction (DDI) of DMQ with memantine, which is also an NMDA receptor antagonist.
引用
收藏
页码：e1 / e15
相关论文
共 50 条
  • [21] Pharmacokinetic and Pharmacodynamic Interactions Between the Immunosuppressant Sirolimus and the Lipid-Lowering Drug Ezetimibe in Healthy Volunteers
    Oswald, S.
    Nassif, A.
    Modess, C.
    Keiser, M.
    Hanke, U.
    Engel, A.
    Luetjohann, D.
    Weitschies, W.
    Siegmund, W.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 (06) : 663 - 667
  • [22] THE PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION BETWEEN LACIDIPINE AND PROPRANOLOL IN HEALTHY-VOLUNTEERS
    HALL, ST
    HARDING, SM
    HASSANI, H
    KEENE, ON
    PELLEGATTI, M
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1991, 18 : S13 - S17
  • [23] Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers
    Kinoshita, Shuji
    Kondo, Kazuoki
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2015, 11 (01) : 7 - 14
  • [24] Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects
    Bruderer, Shirin
    Okubo, Kaori
    Mukai, Hideya
    Mant, Tim
    Dingemanse, Jasper
    CLINICAL THERAPEUTICS, 2016, 38 (05) : 1228 - 1236
  • [25] Pharmacodynamic and pharmacokinetic correlation of terazocin in healthy volunteers
    Usha, PR
    Naidu, MUR
    Kumar, TR
    Vijaykumar, T
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (06) : A124 - A124
  • [26] Pharmacokinetic and pharmacodynamic characterization of gliclazide in healthy volunteers
    Hosoon Kim
    Minhyuk Yun
    Kwang-il Kwon
    Archives of Pharmacal Research, 2003, 26 : 564 - 568
  • [27] Pharmacokinetic and pharmacodynamic characterization of gliclazide in healthy volunteers
    Kim, H
    Yun, M
    Kwon, KI
    ARCHIVES OF PHARMACAL RESEARCH, 2003, 26 (07) : 564 - 568
  • [28] INVESTIGATION OF A POSSIBLE PHARMACOKINETIC INTERACTION BETWEEN NISOLDIPINE AND QUINIDINE IN HEALTHY-VOLUNTEERS
    SCHALL, R
    MULLER, FO
    GROENEWOUD, G
    HUNDT, HKL
    LUUS, HG
    VANDYK, M
    VANSCHALKWYK, AMC
    DRUG INVESTIGATION, 1994, 8 (03): : 162 - 170
  • [29] Pharmacokinetic interactions between theophylline and prulifloxacin in healthy volunteers
    Fattore, C
    Cipolla, G
    Gatti, G
    Bartoli, A
    Orticelli, G
    Picollo, R
    Millerioux, L
    Ciottoli, GB
    Perucca, E
    CLINICAL DRUG INVESTIGATION, 1998, 16 (05) : 387 - 392
  • [30] Pharmacokinetic Interactions between Theophylline and Prulifloxacin in Healthy Volunteers
    C. Fattore
    G. Cipolla
    G. Gatti
    A. Bartoli
    G. Orticelli
    R. Picollo
    L. Millerioux
    G. B. Ciottoli
    E. Perucca
    Clinical Drug Investigation, 1998, 16 : 387 - 392
12345