Barrett's esophagus in 2012: Updates in pathogenesis, treatment, and surveillance

被引：6
作者：
Chandra S. [1 ]
Gorospe E.C. [1 ]
Leggett C.L. [1 ]
Wang K.K. [1 ]
机构：
[1] Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905
来源：
Current Gastroenterology Reports | 2013年 / 15卷 / 5期
关键词：
Acid reflux; Barrett's esophagus; Biomarkers; Confocal laser endomicroscopy; Cryotherapy; Endoscopic mucosal resection; Esophageal adenocarcinoma; Narrow band imaging; Obesity; Optical coherence tomography; Photodynamic therapy; Radiofrequency ablation;
D O I：
10.1007/s11894-013-0322-8
中图分类号：
学科分类号：
摘要：
Barrett's esophagus (BE) is the only established precursor lesion in the development of esophageal adenocarcinoma (EAC) and it increases the risk of cancer by 11-fold. It is regarded as a complication of gastroesophageal reflux disease. There is an ever-increasing body of knowledge on the pathogenesis, diagnosis, treatment, and surveillance of BE and its associated dysplasia. In this review, we summarize the latest advances in BE research and clinical practice in the past 2 years. It is critical to understand the molecular underpinnings of this disorder to comprehend the clinical outcomes of the disease. For clinical gastroenterologists, there is also continuous growth of endoscopic approaches which is daunting, and further improvements in the detection and treatment of BE and early EAC are anticipated. In the future, we may see the increased role of biomarkers, both molecular and imaging, in both diagnostic and therapeutic strategies for BE. © 2013 Springer Science+Business Media New York.
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  • [31] Mino-Kenudson M., Hull M.J., Brown I., Muzikansky A., Srivastava A., Glickman J., Park D.-Y., Zuckerberg L., Misdraji J., Odze R.D., Lauwers G.Y., EMR for Barrett's esophagus-related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy, Gastrointestinal Endoscopy, 66, 4, pp. 660-666, (2007)
  • [32] Pech O., Bollschweiler E., Manner H., Leers J., Ell C., Holscher A.H., Comparison between endoscopic and surgical resection of mucosal esophageal adenocarcinoma in Barrett's esophagus at two highvolume centers, Ann Surg, 254, 1, pp. 67-72, (2011)
  • [33] Van Vilsteren F.G., Pouw R.E., Herrero L.A., Et al., Learning to perform endoscopic resection of esophageal neoplasia is associated with significant complications even within a structured training program, Endoscopy, 44, 1, pp. 4-12, (2012)
  • [34] Alvarez Herrero L., Pouw R.E., Van Vilsteren F.G., Et al., Safety and efficacy of multiband mucosectomy in 1060 resections in Barrett's esophagus, Endoscopy, 43, 3, pp. 177-183, (2011)
  • [35] Shaheen N.J., Sharma P., Overholt B.F., Et al., Radiofrequency ablation in Barrett's esophagus with dysplasia, N Engl J Med, 360, 22, pp. 2277-2288, (2009)
  • [36] Yoon S.S., Rivera R., Antignano L., Kaul V., A case of mediastinitis after radiofrequency ablation for Barrett's esophagus, Gastrointest Endosc, 74, 6, pp. 1407-1408, (2011)
  • [37] Shaheen N.J., Overholt B.F., Sampliner R.E., Et al., Durability of radiofrequency ablation in Barrett's esophagus with dysplasia, Gastroenterology, 141, 2, pp. 460-468, (2011)
  • [38] Okoro N.I., Tomizawa Y., Dunagan K.T., Lutzke L.S., Wang K.K., Prasad G.A., Safety of prior endoscopic mucosal resection in patients receiving radiofrequency ablation of Barrett's esophagus, Clin Gastroenterol Hepatol, 10, 2, pp. 150-154, (2012)
  • [39] Fleischer D.E., Overholt B.F., Sharma V.K., Et al., Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial, Endoscopy, 42, 10, pp. 781-789, (2010)
  • [40] Gupta M., Lutzke L.S., Prasad G.A., Et al., Recurrence of intestinal metaplasia after eradication of Barrett's esophagus with radio frequency ablation - Results from a BETRNet consortium, Gastroenterology, 142, 5, (2012)
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