Barrett's esophagus in 2012: Updates in pathogenesis, treatment, and surveillance

被引：6
作者：
Chandra S. [1 ]
Gorospe E.C. [1 ]
Leggett C.L. [1 ]
Wang K.K. [1 ]
机构：
[1] Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905
来源：
Current Gastroenterology Reports | 2013年 / 15卷 / 5期
关键词：
Acid reflux; Barrett's esophagus; Biomarkers; Confocal laser endomicroscopy; Cryotherapy; Endoscopic mucosal resection; Esophageal adenocarcinoma; Narrow band imaging; Obesity; Optical coherence tomography; Photodynamic therapy; Radiofrequency ablation;
D O I：
10.1007/s11894-013-0322-8
中图分类号：
学科分类号：
摘要：
Barrett's esophagus (BE) is the only established precursor lesion in the development of esophageal adenocarcinoma (EAC) and it increases the risk of cancer by 11-fold. It is regarded as a complication of gastroesophageal reflux disease. There is an ever-increasing body of knowledge on the pathogenesis, diagnosis, treatment, and surveillance of BE and its associated dysplasia. In this review, we summarize the latest advances in BE research and clinical practice in the past 2 years. It is critical to understand the molecular underpinnings of this disorder to comprehend the clinical outcomes of the disease. For clinical gastroenterologists, there is also continuous growth of endoscopic approaches which is daunting, and further improvements in the detection and treatment of BE and early EAC are anticipated. In the future, we may see the increased role of biomarkers, both molecular and imaging, in both diagnostic and therapeutic strategies for BE. © 2013 Springer Science+Business Media New York.
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  • [1] Wang K.K., Endoscopic vs surgical resection for Barrett's intramucosal adenocarcinoma: Beyond a therapeutic equipoise, Gastroenterology, 143, 1, pp. 257-259, (2012)
  • [2] Peters F.P., Curvers W.L., Rosmolen W.D., Et al., Surveillance history of endoscopically treated patients with early Barrett's neoplasia: Nonadherence to the Seattle biopsy protocol leads to sampling error, Dis Esophagus, 21, 6, pp. 475-479, (2008)
  • [3] Prasad G.A., Wang K.K., Halling K.C., Et al., Correlation of histology with biomarker status after photodynamic therapy in Barrett esophagus, Cancer, 113, 3, pp. 470-476, (2008)
  • [4] Sarosi G., Brown G., Jaiswal K., Et al., Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus, Dis Esophagus, 21, 1, pp. 43-50, (2008)
  • [5] Hutchinson L., Stenstrom B., Chen D., Et al., Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant, Stem Cells Dev, 20, 1, pp. 11-17, (2011)
  • [6] Bianchi N.O., Y chromosome structural and functional changes in human malignant diseases, Mutat Res, 682, 1, pp. 21-27, (2009)
  • [7] Orlando R.C., Pathophysiology of gastroesophageal reflux disease, Journal of Clinical Gastroenterology, 42, 5, pp. 584-588, (2008)
  • [8] Souza R.F., Huo X., Mittal V., Et al., Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury, Gastroenterology, 137, 5, pp. 1776-1784, (2009)
  • [9] Yoshida N., Imamoto E., Uchiyama K., Et al., Molecular mechanisms involved in interleukin-8 production by normal human oesophageal epithelial cells, Aliment Pharmacol Ther Symp ser, 2, 1, pp. 219-226, (2006)
  • [10] Fitzgerald R.C., Onwuegbusi B.A., Bajaj-Elliott M., Saeed I.T., Burnham W.R., Farthing M.J.G., Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: Immunological determinants, Gut, 50, 4, pp. 451-459, (2002)
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