Acute lung injury: a view from the perspective of necroptosis

被引：9

作者：

Dong, Jinyan ^{[1
]}

Liu, Weihong ^{[3
]}

Liu, Wenli ^{[1
]}

Wen, Yuqi ^{[2
]}

Liu, Qingkuo ^{[1
]}

Wang, Hongtao ^{[1
]}

Xiang, Guohan ^{[1
]}

Liu, Yang ^{[3
]}

Hao, Hao ^{[3
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250000, Shandong, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Clin Med Coll 2, Jinan 250000, Shandong, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250000, Shandong, Peoples R China

来源：

INFLAMMATION RESEARCH | 2024年 / 73卷 / 06期

关键词：

Necroptosis; Apoptosis; Pyroptosis; Autophagy; Coagulation; Fibrosis; PHOSPHOLIPASE-D; PYROPTOSIS; SEPSIS; ACTIVATION; EXPRESSION;

D O I：

10.1007/s00011-024-01879-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

BackgroundALI/ARDS is a syndrome of acute onset characterized by progressive hypoxemia and noncardiogenic pulmonary edema as the primary clinical manifestations. Necroptosis is a form of programmed cell necrosis that is precisely regulated by molecular signals. This process is characterized by organelle swelling and membrane rupture, is highly immunogenic, involves extensive crosstalk with various cellular stress mechanisms, and is significantly implicated in the onset and progression of ALI/ARDS.MethodsThe current body of literature on necroptosis and ALI/ARDS was thoroughly reviewed. Initially, an overview of the molecular mechanism of necroptosis was provided, followed by an examination of its interactions with apoptosis, pyroptosis, autophagy, ferroptosis, PANOptosis, and NETosis. Subsequently, the involvement of necroptosis in various stages of ALI/ARDS progression was delineated. Lastly, drugs targeting necroptosis, biomarkers, and current obstacles were presented.ConclusionNecroptosis plays an important role in the progression of ALI/ARDS. However, since ALI/ARDS is a clinical syndrome caused by a variety of mechanisms, we emphasize that while focusing on necroptosis, it may be more beneficial to treat ALI/ARDS by collaborating with other mechanisms.

引用

页码：997 / 1018

页数：22

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