18FDG PET study of amygdalar activity during facial emotion recognition in schizophrenia

被引：0
作者：
Emilio Fernandez-Egea
Eduard Parellada
Francisco Lomeña
Carles Falcon
Javier Pavia
Anna Mane
Guillermo Horga
Miguel Bernardo
机构：
[1] Hospital Clinic,Department of Psychiatry, Institute of Neuroscience
[2] Hospital Clinic,Nuclear Medicine, Institut de Diagnostic per Imatge
[3] Universitat de Barcelona,Unitat de Biofísica i Bioengineria, Facultat de Medicina
[4] Biomateriales y Nanomedicina (CIBER-BBN),Centro de Investigación Biomédica en Red en Bioingeneria
[5] Institut d’Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS),Servei de Psiquiatría, Institut Clínic de Neurociències
[6] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM),undefined
[7] Hospital Clínic,undefined
来源：
European Archives of Psychiatry and Clinical Neuroscience | 2010年 / 260卷
关键词：
Nuclear medicine; Limbic system; Hemispheric specialization; Positron emission tomography; Emotion; Negative symptoms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of the amygdala during facial emotion recognition (FER) tasks as well as its clinical implications in schizophrenia patients remains unclear. While most of authors have reported hypoactivation, recently it has been suggested that patients may also exhibit hyperactivation. We studied amygdalar response during a previously validated FER task using 18[F] fluorodeoxyglucose positron emission tomography (18FDG-PET) technique in ten right-handed healthy volunteers and 11 right-handed non acute patients with schizophrenia. Both groups underwent two scans on different days in a random order; each consisted of 17 1/2 min of continuous emotional and control tasks. Statistical Parametric Mapping (SPM) 2 analysis with a region of interest approach was carried out. Left amygdalar hyperactivation among the schizophrenia group was shown in both emotional and control tasks when compared to healthy subjects. The right amygdala showed no differential activation in any of the tasks. Patients diagnosed with schizophrenia exhibit a non-task specific amygdalar hyperactivation during a continuous emotional and non-emotional task when compared to matched healthy controls.
引用
收藏
页码：69 / 76
页数：7
相关论文
共 272 条
  • [1] Adolphs R(1994)Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala Nature 372 669-672
  • [2] Tranel D(2005)Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Prog Neurobiol 77 283-298
  • [3] Damasio H(2004)Lateralization of amygdala activation: a systematic review of functional neuroimaging studies Brain Res Brain Res Rev 45 96-103
  • [4] Damasio A(2005)Understanding the recognition of facial identity and facial expression Nat Rev Neurosci 6 641-651
  • [5] Aleman A(2008)Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies Brain Res Rev 58 57-70
  • [6] Kahn RS(2001)The amygdala: vigilance and emotion Mol Psychiatry 6 13-34
  • [7] Baas D(2002)Emotion, cognition, and behavior Science 298 1191-1194
  • [8] Aleman A(2002)Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review Clin Psychol Rev 22 789-832
  • [9] Kahn RS(2008)Neural bases of different cognitive strategies for facial affect processing in schizophrenia Schizophr Res 100 191-205
  • [10] Calder AJ(2008)Keep smiling! facial reactions to emotional stimuli and their relationship to emotional contagion in patients with schizophrenia Eur Arch Psychiatry Clin Neurosci 258 245-253
12345678910