Ancestry informative markers and admixture proportions in northeastern Mexico

被引：0

作者：

Margarita L Martinez-Fierro

Joke Beuten

Robin J Leach

Esteban J Parra

Miguel Cruz-Lopez

Hector Rangel-Villalobos

Lina R Riego-Ruiz

Rocio Ortiz-Lopez

Herminia G Martinez-Rodriguez

Augusto Rojas-Martinez

机构：

[1] School of Medicine,Department of Biochemistry and Molecular Medicine

[2] Universidad Autonoma de Nuevo Leon,Department of Cellular and Structural Biology

[3] University of Texas Health Science Center at San Antonio,Department of Anthropology

[4] San Antonio,Division of Molecular Biology

[5] University of Toronto at Mississauga,undefined

[6] Ontario,undefined

[7] Canada,undefined

[8] Unit of Medical Biochemistry,undefined

[9] Centro Medico Nacional Siglo XXI,undefined

[10] Molecular Genetics Institute,undefined

[11] Centro Universitario de la Cienega,undefined

[12] Universidad de Guadalajara (CUCienega-UdeG),undefined

[13] Ocotlán,undefined

[14] Instituto Potosino de Investigacion Cientifica y Tecnológica,undefined

来源：

Journal of Human Genetics | 2009年 / 54卷

关键词：

AIMs; admixture; ancestry; markers; population; Y-SNPs;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To investigate the ancestral admixture in the Mestizo population in northeastern Mexico, we genotyped 74 ancestral informative markers (AIMs) and 15 Y-single-nucleotide polymorphisms (Y-SNPs) in 100 individuals. The Native American contribution is 56% (range: 27.4–81.2%), the European contribution is 38% (range: 16.7–70.5%) and the West African contribution is 6%. The results show a higher European contribution than was reported in other similar studies in the country, albeit with a predominant Native American ancestry. No remarkable differences in the ancestry proportions were observed using subgroups of 74, 54, 34 and 24 AIMs. The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers (∼78%), compared with Amerindian (∼12%) and African markers (10%). This information will set a reference for future determinations of admixture proportions in the Mestizo population from Mexico and for population-based association studies of complex diseases.

引用

页码：504 / 509

页数：5

共 157 条

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