193 The Rna-Binding Protein Rbm3 is Involved in Hypothermia Induced Neuroprotection

被引：0

作者：

S Wellmann

A Zelmer

C Nitsch

H U Bucher

C Bührer

机构：

[1] University Hospital Zürich,Department of Neonatology

[2] University Children's Hospital Basel,Department of Neonatology

[3] University Basel,Department of Neuroanatomy

[4] Charité University Medical Center,Department of Neonatology

来源：

Pediatric Research | 2010年 / 68卷

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摘要：

Background: Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. While hypothermia downregulates global protein synthesis and cell metabolism, low temperature induces a small subset of proteins that includes the RNA-binding protein RBM3, which is transcriptionally induced also in response to hypoxia and has recently been implicated in cell survival.

引用

页码：101 / 101