Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

被引:0
作者
Ivan D Mascanfroni
Maisa C Takenaka
Ada Yeste
Bonny Patel
Yan Wu
Jessica E Kenison
Shafiuddin Siddiqui
Alexandre S Basso
Leo E Otterbein
Drew M Pardoll
Fan Pan
Avner Priel
Clary B Clish
Simon C Robson
Francisco J Quintana
机构
[1] Center for Neurologic Diseases,Division of Gastroenterology
[2] Brigham and Women's Hospital,Department of Microbiology
[3] Harvard Medical School,Immunology and Hematopoiesis Division, Department of Oncology and Medicine
[4] Hepatology and Transplantation,Department of Physics
[5] Beth Israel Deaconess Medical Center,undefined
[6] Harvard Medical School,undefined
[7] Immunology and Parasitology,undefined
[8] Escola Paulista de Medicina,undefined
[9] Federal University of São Paulo,undefined
[10] Johns Hopkins University School of Medicine,undefined
[11] University of Alberta,undefined
[12] Center for Proteomics,undefined
[13] The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard,undefined
来源
Nature Medicine | 2015年 / 21卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Metabolic changes induced by hypoxia and extracellular ATP, acting through the transcription factors HIF1-α and AHR, regulate the differentiation of type 1 regulatory (Treg1) cells.
引用
收藏
页码:638 / 646
页数:8
相关论文
共 50 条
  • [31] A T follicular helper cell origin for T regulatory type 1 cells
    Sole, Patricia
    Yamanouchi, Jun
    Garnica, Josep
    Uddin, Muhammad Myn
    Clarke, Robert
    Moro, Joel
    Garabatos, Nahir
    Thiessen, Shari
    Ortega, Mireia
    Singha, Santiswarup
    Mondal, Debajyoti
    Fandos, Cesar
    Saez-Rodriguez, Julio
    Yang, Yang
    Serra, Pau
    Santamaria, Pere
    CELLULAR & MOLECULAR IMMUNOLOGY, 2023, 20 (05) : 489 - 511
  • [32] Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation
    Wu, Chuan
    Pot, Caroline
    Apetoh, Lionel
    Thalhamer, Theresa
    Zhu, Bing
    Murugaiyan, Gopal
    Xiao, Sheng
    Lee, Youjin
    Rangachari, Manu
    Yosef, Nir
    Kuchroo, Vijay K.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) : 7802 - 7807
  • [33] The functional and clinicopathological analysis of hypoxia inducible factor-1α (HIF1-α) in head and neck squamous cell carcinoma
    Ikari, Yuichi
    Ozawa, Hiroyuki
    Imanishi, Yorihisa
    Tomita, Toshiki
    Sekimizu, Mariko
    Watanabe, Yoshihiro
    Ito, Fumihiro
    Saito, Shin
    Ogawa, Kaoru
    CANCER RESEARCH, 2017, 77
  • [34] Metabolic activity of esophageal adenocarcinoma assessed by positron emission tomography:: Effect of neoadjuvant chemoradiotherapy, GLUT-1 and HIF1-α expression
    Raouf, A
    Power, C
    Ravi, N
    Griffin, M
    Reynolds, J
    GASTROENTEROLOGY, 2005, 128 (04) : A574 - A574
  • [35] HIF1-α-Mediated Gene Expression Induced by Vitamin B1 Deficiency
    Sweet, Rebecca L.
    Zastre, Jason A.
    INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 2013, 83 (03) : 188 - 197
  • [36] Multifaceted control of T cell differentiation by STIM1
    Gross, Scott
    Womer, Lauren
    Kappes, Dietmar J.
    Soboloff, Jonathan
    TRENDS IN BIOCHEMICAL SCIENCES, 2023, 48 (12) : 1083 - 1097
  • [37] PD-1 regulates extrathymic regulatory T-cell differentiation
    Chen, Xiufen
    Fosco, Dominick
    Kline, Douglas E.
    Meng, Liping
    Nishi, Saki
    Savage, Peter A.
    Kline, Justin
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (09) : 2603 - 2616
  • [38] Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis
    Cheng, Hsin-Yuan
    Gaddis, Dalia E.
    Wu, Runpei
    McSkimming, Chantel
    Haynes, LaTeira D.
    Taylor, Angela M.
    McNamara, Coleen A.
    Sorci-Thomas, Mary
    Hedrick, Catherine C.
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (09) : 3236 - 3246
  • [39] Type 1 T regulatory cells
    Roncarolo, MG
    Bacchetta, R
    Bordignon, C
    Narula, S
    Levings, MK
    IMMUNOLOGICAL REVIEWS, 2001, 182 : 68 - 79
  • [40] Role of AHR and HIF-1α in Glioblastoma Metabolism
    Gabriely, Galina
    Wheeler, Michael A.
    Takenaka, Maisa C.
    Quintana, Francisco J.
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2017, 28 (06) : 428 - 436