Granite as a high-quality stone, widely used in all walks of life, but in the grinding process of granite stone, produced a large number of granite stone powder, and most of these stone powders have not been rational use. Therefore, the use of a large amount of waste granite powder as a mineral admixture to prepare concrete can not only solve the problem of limited traditional mineral admixtures but also solve the problem of environmental pollution caused by waste granite powder. Through slump test, rheological property test, free water test, and zeta potential test, it is shown that the layered structure of stone powder can lead to ion adsorption and water adsorption, thus reducing the slump. For the compressive strength, it shows a trend of increasing first and then decreasing. ICP shows that the replacement of stone powder leads to the decrease of early effective components. Nanoindentation and SEM–EDS show that the addition of stone powder affects the hydration products. The MIP results correspond to the compressive strength results, indicating that the durability decreases first and then increases with the increase of the substitution rate, so it is necessary to consider the reasonable addition amount of stone powder. Since the stone powder only needs to be ground to avoid the related process of cement, good economic and environmental benefits can be obtained with the increase of substitution rate.