Synthesis, anti-inflammatory and antinociceptive activity of some novel benzothiazole derivatives

被引：0
作者：
Eman M. H. Abbas
Kamelia M. Amin
Wageeh S. El-Hamouly
Dina H. Dawood
Mohamed M. Abdalla
机构：
[1] National Research Center,Department of Chemistry of Natural and Microbial Products
[2] Cairo University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[3] Saco Pharm. Co,Research Unit
来源：
Research on Chemical Intermediates | 2015年 / 41卷
关键词：
Benzothiazol-2-one; Benzothiazole; Anti-inflammatory; Antinocicepative;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new series of derivatives bearing benzothiazol-2-one or benzothiazole ring system conjugated to other different heterocycles were prepared using 5,6-dimethoxy-3-benzothiazol-2(3H)-one (1) as a starting material. The structures of the newly synthesized products have been established based on analytical and spectral data. In addition, the anti-inflammatory and antinociceptive activities of some of the products were evaluated. Our data showed that many derivatives have promising activities as anti-inflammatory and antinocicepative agents.
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页码：2537 / 2555
页数：18
相关论文
共 123 条
[1]  
Laddha SS(2006)undefined Arkivoc 11 1-20
[2]  
Wadodkar SG(2009)undefined Arkivoc 6 89-102
[3]  
Meghal SK(2009)undefined Acta. Poloniae. Pharm. 66 387-392
[4]  
Argyropoulou I(2003)undefined Mol. Cancer Ther. 2 1265-1272
[5]  
Geronikaki A(1999)undefined J. Med. Chem. 42 4172-4179
[6]  
Vicini P(1988)undefined J. Med. Chem. 41 1138-1145
[7]  
Zani F(1998)undefined II Farmaco 53 80-84
[8]  
Shaharyar M(1999)undefined II Farmaco 54 846-851
[9]  
Ansari ZH(2000)undefined Arch. Pharm. Pharm. Med. 333 337-340
[10]  
Hose CD(2000)undefined J. Environ. Monit. 2 73-76
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