Ghrelin and Obestatin Levels in Type 2 Diabetic Patients With and Without Delayed Gastric Emptying

被引：0
作者：
Igor A. Harsch
Corinna Koebnick
Atingwa M. Tasi
Eckhart Georg Hahn
Peter C. Konturek
机构：
[1] Friedrich-Alexander University Erlangen-Nuremberg,Department of Medicine 1, Division of Endocrinology and Metabolism
[2] Southern California Permanente Medical Group,Department of Research and Evaluation
[3] Klinikum Lippe-Detmold,Department of Surgery
[4] Friedrich-Alexander University Erlangen-Nuremberg,Department of Medicine 1
来源：
Digestive Diseases and Sciences | 2009年 / 54卷
关键词：
Ghrelin; Obestatin; Diabetes mellitus; Gastroparesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alterations in the neurohumoral regulation of the upper intestine may change rhythmicity and pattern of ghrelin and obestatin, the latter presumably antagonizing ghrelin effects. Five nongastroparetic diabetic patients and five with gastroparesis were investigated. Over 390 min including breakfast and lunch, ghrelin was significantly lower in patients with gastroparesis compared with in those without (P = 0.015). Ghrelin subsequent to lunch decreased significantly (P = 0.011) in patients without gastroparesis, but not in gastroparetic patients (P = 0.669). Obestatin was similar in both groups and unchanged. No significant differences in ghrelin-to-obestatin ratio were observed (P = 0.530). Loss of rhythmicity in the ghrelin levels of gastroparetic diabetics highlights the importance of integrity of the neurohumoral-intestinal axis. Stable diurnal obestatin levels do not support the concept of interaction between ghrelin and obestatin in terms of regulation of food intake and gastric emptying.
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页码：2161 / 2166
页数：5
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