Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

被引：0
作者：
Amir Abbas Momtazi
Giuseppe Derosa
Pamela Maffioli
Maciej Banach
Amirhossein Sahebkar
机构：
[1] Mashhad University of Medical Sciences,Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine
[2] University of Pavia,Center for the Study of Endocrine
[3] University of Pavia and Fondazione IRCCS Policlinico S. Matteo,Metabolic Pathophysiology and Clinical Research
[4] Medical University of Lodz,Department of Internal Medicine and Therapeutics
[5] Medical University of Lodz,Department of Hypertension
[6] Mashhad University of Medical Sciences,Healthy Aging Research Centre (HARC)
[7] University of Western Australia,Biotechnology Research Center
来源：
Molecular Diagnosis & Therapy | 2016年 / 20卷
关键词：
Curcumin; Diabetic Nephropathy; Curcuma Longa; APOE Knockout Mouse; PTP1B Expression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.
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页码：335 / 345
页数：10
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