Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometry

被引：46
作者：
Liang Z. [1 ]
Chen H. [1 ]
Yu Z. [1 ]
Zhao Z. [1 ]
机构：
[1] School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR
来源：
Chinese Medicine | / 5卷 / 1期
关键词：
High Performance Liquid Chromatography; Glucoside; Anthraquinone; Chinese Pharmacopoeia; High Performance Liquid Chromatography Condition;
D O I：
10.1186/1749-8546-5-29
中图分类号：
学科分类号：
摘要：
Background: Radix Polygoni Multiflori is the dried root tuber of Polygonum multiflorum Thunb. (Fam. Polygonaceae). According to Chinese medicine theory, raw (R-RPM) and processed (P-RPM) Radix Polygoni Multiflori possess different properties. The present study investigates the differences in chemistry between raw and processed Radix Polygoni Multiflori.Methods: Five pairs of R-RPM and P-RPM as well as 15 commercial decoction pieces were analyzed with high performance liquid chromatography (HPLC) and mass spectrometry (MS).Results: Two anthraquinones, namely emodin-8-O-(6'-O-malonyl)-glucoside and physcion-8-O-(6'-O-malonyl)-glucoside disappeared or decreased significantly and 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside, emodin-8-O-β-D-glucopyranoside and physcion-8-O-β-D-glucopyranoside decreased after the R-RPM samples being processed. On the other hand, the contents of emodin and physcion generally increased after processing.Conclusion: The present study indicates that processing Radix Polygoni Multiflori may change the contents and types of chemicals in it. These changes are probably responsible for the various pharmacological effects of R-RPM and P-RPM as well as hepatotoxicity. © 2010 Liang et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 34 条
[11]  
Park G.J.H., Mann S.P., Ngu M.C., Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum, J Gastroenterol Hepatol, 16, pp. 115-117, (2001)
[12]  
Mazzanti G., Battinelli L., Daniele C., Mastroianni C.M., Lichtner M., Coletta S., Costantini S., New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum, Ann Intern Med, 140, (2004)
[13]  
Panis B., Wong D.R., Hooymans P.M., De Smet P.A., Rosias P.P., Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation, J Pediatr Gastroenterol Nutr, 41, pp. 256-258, (2005)
[14]  
Cardenas A., Restrepo J.C., Sierra F., Correa G., Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum, J Clin Gastroenterol, 40, pp. 629-632, (2006)
[15]  
Yuen M.F., Tam S., Fung J., Wong D.K., Wong B.C., Lai C.L., Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study, Aliment Pharmacol Ther, 24, pp. 1179-1186, (2006)
[16]  
Laird A.R., Ramchandani N., deGoma E.M., Avula B., Khan I.A., Gesundheit N., Acute hepatitis associated with the use of an herbal supplement mimicking iron-overload syndrome, J Clin Gastroenterol, 42, pp. 861-862, (2008)
[17]  
Ye Q.H., A case report about acute toxic hepatopathy induced by Radix Polygoni Multiflori, Chin J Integ Trad West Med, 16, (1996)
[18]  
Sheng J.Q., Familial injury induced by Radix Polygoni Multiflori, Chin J Hepatol, 6, (1998)
[19]  
Zhang X., Ding X.C., Six cases' report about liver injury induced by Radix Polygoni Multiflori, J Ningxia Med Coll, 22, (2000)
[20]  
Yang D.Q., Heshouwu-related several liver impairment, Adv Drug React J, 6, (2005)
1234