Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34

被引：0
作者：
Ratklao Siriwach
Hiroshi Kinoshita
Shigeru Kitani
Yasuhiro Igarashi
Kanokthip Pansuksan
Watanalai Panbangred
Takuya Nihira
机构：
[1] International Center for Biotechnology,Department of Biotechnology
[2] Osaka University,undefined
[3] 2-1 Yamadaoka,undefined
[4] Biotechnology Research Center,undefined
[5] Toyama Prefectural University,undefined
[6] 5180 Kurokawa,undefined
[7] Faculty of Science,undefined
[8] Mahidol University,undefined
[9] MU-OU Collaborative Research Center for Bioscience and Biotechnology,undefined
[10] Faculty of Science,undefined
[11] Mahidol University,undefined
来源：
The Journal of Antibiotics | 2014年 / 67卷
关键词：
endophytic fungi; triene amide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
As a result of the continued screening for new metabolites produced by endophytic fungi from Thai medicinal plants, two new triene fatty acid amides, bipolamides A (1) and B (2), were discovered from the endophytic fungus Bipolaris sp. MU34. The structures of all of the isolated compounds were elucidated on the basis of the spectroscopic data of NMR and MS. An antimicrobial assay revealed that bipolamide B (2) had moderate antifungal activity against Cladosporium cladosporioides FERMS-9, Cladosporium cucumerinum NBRC 6370, Saccharomyces cerevisiae ATCC 9804, Aspergillus niger ATCC 6275 and Rhisopus oryzae ATCC 10404, with Minimum inhibitory concentration (MIC) values of 16, 32, 32, 64 and 64 μg ml−1, respectively.
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页码：167 / 170
页数：3
相关论文
共 48 条
[1]  
Schulz B(2002)Endophytic fungi: a source of novel biologically active secondary metabolites Mycol. Res. 106 996-1004
[2]  
Boyle C(2004)Natural products from endophytic microorganisms J. Nat. Prod. 67 257-268
[3]  
Draeger S(2008)Bioactive natural products from endophytes: a review Appl. Biochem. Microbiol. 44 136-142
[4]  
Römmert A-K(2009)Fungal endophytes and bioprospecting Fungal Biol. Rev. 23 9-19
[5]  
Krohn K(2007)Antimalarial benzoquinones from an endophytic fungus, J. Nat. Prod. 70 1620-1623
[6]  
Strobel G(2006) sp J. Nat. Prod. 69 856-858
[7]  
Daisy B(2008)Pimarane diterpene and cytochalasin derivatives from the endophytic fungus J. Nat. Prod. 71 1657-1659
[8]  
Castillo U(2008) PSU-D44 Phytochemistry 69 783-787
[9]  
Harper J(2011)11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum J. Antibiot. 64 217-219
[10]  
Guo B(2012)Metabolites from the endophytic fungus J. Antibiot. 65 627-629
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