New synthesis of estradiol from androsta-1,4-diene-3,17-dione

被引：0
作者：
L. L. Vasiljeva
P. M. Demin
D. M. Kochev
M. A. Lapitskaya
K. K. Pivnitsky
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[2] “Pentcroft Pharma” Company,undefined
来源：
Russian Chemical Bulletin | 1999年 / 48卷
关键词：
androsta-1,4-diene-3,17-dione; aromatization; angular demethylation; estradiol; partial synthesis;
D O I：
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学科分类号：
摘要：
A new method for the aromatization of ring A in androsta-1,4-diene-3,17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1,4-diene-3,17-dione to the corresponding dienediol followed by double C,O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.
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页码：593 / 595
页数：2
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