Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

被引：0

作者：

Jin Chen

Junqiu Chen

Yuanhang Cheng

Yunfeng Fu

Hongzhou Zhao

Minying Tang

Hu Zhao

Na Lin

Xiaohua Shi

Yan Lei

Shuiliang Wang

Lianghu Huang

Weizhen Wu

Jianming Tan

机构：

[1] Xiamen University,Fujian Provincial Key Laboratory of Transplant Biology, 900th Hospital

[2] Clinical Medical Institute of Fujian Medical University,Organ Transplant Institute, 900th Hospital

[3] Hubei University of Arts and Science,Xiangyang Central Hospital

来源：

Stem Cell Research & Therapy | / 11卷

关键词：

Mesenchymal stem cells; Exosomes; Hypoxia; Beta cells; ER stress;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 40 条

[21] Exosomes derived from mir-337-3p over-expressing tendon stem cells protect against apoptosis of tenocytes via targeting caspase3
An, Qing
Zhou, Zipeng
Xu, Chang
Xiao, Qiang
BMC MUSCULOSKELETAL DISORDERS, 2024, 25 (01)
[22] miR-666-3p Mediates the Protective Effects of Mesenchymal Stem Cell-derived Exosomes Against Oxygen-glucose Deprivation and Reoxygenation-induced Cell Injury in Brain Microvascular Endothelial Cells via Mitogen-activated Protein Kinase Pathway
Kong, Li-yun
Li, Yan
Rao, Ding-yu
Wu, Bing
Sang, Cheng-peng
Lai, Ping
Ye, Jun-song
Zhang, Zu-xiong
Du, Zhi-ming
Yu, Jun-jian
Gu, Liang
Xie, Fa-chun
Liu, Zi-you
Tang, Zhi-xian
CURRENT NEUROVASCULAR RESEARCH, 2021, 18 (01) : 20 - 77
[23] microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation
Cui, Shaoqian
Zhang, Lei
JOURNAL OF TISSUE ENGINEERING, 2021, 12
[24] Exosomes from adipose-derived mesenchymal stem cells improve liver fibrosis by regulating the miR-20a-5p/TGFBR2 axis to affect the p38 MAPK/NF-κB pathway
Gan, Lihong
Zheng, Li
Yao, Ling
Lei, Ling
Huang, Yaqin
Zeng, Zhiping
Fang, Nian
CYTOKINE, 2023, 172
[25] Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src
Xiao, Xian
Xu, Meiqian
Yu, Hongliang
Wang, Liping
Li, Xiaoxia
Rak, Janusz
Wang, Shihua
Zhao, Robert Chunhua
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
[26] Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3
Yi, Xiaomeng
Wei, Xuxia
Lv, Haijin
An, Yuling
Li, Lijuan
Lu, Pinglan
Yang, Yang
Zhang, Qi
Yi, Huimin
Chen, Guihua
EXPERIMENTAL CELL RESEARCH, 2019, 383 (02)
[27] Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p
Xin, Danqing
Li, Tingting
Chu, Xili
Ke, Hongfei
Yu, Zhuoya
Cao, Lili
Bai, Xuemei
Liu, Dexiang
Wang, Zhen
ACTA BIOMATERIALIA, 2020, 113 (113) : 597 - 613
[28] MiR-129-5p shuttled by human synovial mesenchymal stem cell-derived exosomes relieves IL-1β induced osteoarthritis via targeting HMGB1
Qiu, Min
Liu, Da
Fu, Qin
LIFE SCIENCES, 2021, 269
[29] Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Loaded Mir-29-3p Targets AhR to Improve Juvenile Idiopathic Arthritis via Inhibiting the Expression of IL-22 in CD4+ T Cell
Wei, Xinyi
Sui, Kunpeng
Peng, Yuanyuan
Li, Sha
Fang, Yu
Chen, Zhi
Du, Xiao
Xie, Xue
Tang, Haiming
Wen, Qiuyue
Li, Jingwei
He, Meilin
Cheng, Qin
Zhang, Wei
STEM CELL REVIEWS AND REPORTS, 2025, 21 (02) : 536 - 553
[30] Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration
Sun, Yongjin
Zhang, Wenzhi
Li, Xu
STEM CELL RESEARCH & THERAPY, 2021, 12 (01)

← 1 2 3 4 →