Use of zwitterionic micelles in the eluent II: a new approach to ion chromatographic analysis of inorganic cations in biological fluids with direct sample injection

被引：0
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作者：
W. Hu
Hidenori Matsukami
Alexander Iles
Kiyoshi Hasebe
Shunan Cao
Kazuhiko Tanaka
机构：
[1] Division of Chemistry,
[2] Graduate School of Science,undefined
[3] Hokkaido University,undefined
[4] Sapporo 060-0810,undefined
[5] Japan e-mail: hu@ees.hokudai.ac.jp,undefined
[6] Division of Material Science,undefined
[7] Graduate School of Environmental Earth Science,undefined
[8] Hokkaido University,undefined
[9] Sapporo 060-0810,undefined
[10] Japan,undefined
[11] Department of Chemistry and Environment,undefined
[12] Wuhan University of Hydraulic and Electric Engineering,undefined
[13] Wuhan,undefined
[14] 430072,undefined
[15] China,undefined
[16] National Industrial Research Institute of Nagoya,undefined
[17] 1-1 Hirate-cho,undefined
[18] Kita-ku,undefined
[19] Nagoya 462-8510,undefined
[20] Japan,undefined
来源：
Fresenius' Journal of Analytical Chemistry | 2001年 / 370卷
关键词：
Detection Limit; Serum Sample; Cation Exchange; Chromatographic Analysis; Simultaneous Determination;
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摘要：
A new ion chromatographic (IC) technique has been developed for the determination of inorganic cations in biological fluids with direct sample injection. This involved the use of a mixed zwitterionic-micelle/electrolyte solution as an eluent. The proteins in the sample became bound to the zwitterionic micelles in the eluent and were thus eliminated from the column. The cations were separated by cation exchange. This method is ideal for the on-line, simultaneous determination of common inorganic cations (Na+, NH4+, K+, Mg2+, and Ca2+) in urine and serum samples. Such an application was demonstrated experimentally. Non-suppressed conductivity was used for analyte detection. The detection limits obtained using this IC system were 2.94, 5.22, 34.9, 32.6, and 56.7 μg/L for Na+, NH4+, K+, Mg2+, and Ca2+, respectively.
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页码：426 / 428
页数：2
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