Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy

[1] Alexander A(2011)The role of LKB1 and AMPK in cellular responses to stress and damage FEBS Lett 585 952-957

[2] Walker CL(2010)ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS Proc Natl Acad Sci U S A 107 4153-4158

[3] Alexander A(2005)Radiation and the microenvironment—tumorigenesis and therapy Nat Rev Cancer 5 867-875

[4] Cai SL(2007)Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 1003-1007

[5] Kim J(2009)Crypt stem cells as the cells-of-origin of intestinal cancer Nature 457 608-611

[6] Nanez A(2009)Rectal cancer staging post neoadjuvant therapy–how should the changes be assessed? Histopathology 54 713-721

[7] Sahin M(2010)Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors Cancer Cell 17 547-559

[8] MacLean KH(2011)The cancer stem cell: premises, promises and challenges Nat Med 17 313-319

[9] Inoki K(2005)Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer Ann Surg 241 829-836

[10] Guan KL(2011)The Lkb1 metabolic sensor maintains haematopoietic stem cell survival Nature 468 659-663

[1] Alexander A(2011)The role of LKB1 and AMPK in cellular responses to stress and damage FEBS Lett 585 952-957

[2] Walker CL(2010)ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS Proc Natl Acad Sci U S A 107 4153-4158

[3] Alexander A(2005)Radiation and the microenvironment—tumorigenesis and therapy Nat Rev Cancer 5 867-875

[4] Cai SL(2007)Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 1003-1007

[5] Kim J(2009)Crypt stem cells as the cells-of-origin of intestinal cancer Nature 457 608-611

[6] Nanez A(2009)Rectal cancer staging post neoadjuvant therapy–how should the changes be assessed? Histopathology 54 713-721

[7] Sahin M(2010)Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors Cancer Cell 17 547-559

[8] MacLean KH(2011)The cancer stem cell: premises, promises and challenges Nat Med 17 313-319

[9] Inoki K(2005)Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer Ann Surg 241 829-836

[10] Guan KL(2011)The Lkb1 metabolic sensor maintains haematopoietic stem cell survival Nature 468 659-663