Basic and Translational Advances in Cancer Metastasis: Nm23

被引:0
作者
Taoufik Ouatas
Massimiliano Salerno
Diane Palmieri
Patricia S. Steeg
机构
[1] National Cancer Institute,Women's Cancers Section, Laboratory of Pathology, Center for Cancer Research
来源
Journal of Bioenergetics and Biomembranes | 2003年 / 35卷
关键词
Nm23; metastasis; suppressor; breast;
D O I
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学科分类号
摘要
Cancer metastasis is a significant contributor to breast cancer patient morbidity and mortality. To develop new anti-metastatic therapies, we need to understand the biological and biochemical mechanisms of metastasis. Toward these efforts, we and others have studied metastasis suppressor genes, which halt metastasis in vivo without affecting primary tumor growth. The first metastasis suppressor gene confirmed was nm23, also known as NDP kinase. Using in vitro assays, nm23 overexpression resulted in reduced anchorage-independent colonization in response to TGF-β, reduced invasion and motility in response to multiple factors, and increased differentiation. We hypothesize that the mechanism of action of Nm23 in metastasis suppression involves diminished signal transduction, downstream of a particular receptor. We hypothesize that a histidine protein kinase activity of Nm23 underlies its suppression of metastasis, and identify candidate substrates. This review also discusses therapeutic options on the basis of reexpression of metastasis suppressors.
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页码:73 / 79
页数:6
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