Systems biology-based approaches to understand HIV-exposed uninfected women

被引：12
作者：
Burgener A. [1 ]
Sainsbury J. [1 ]
Plummer F.A. [1 ]
Blake Ball T. [1 ]
机构：
[1] National Laboratory for HIV Immunology, Public Health Agency of Canada, H-3440, Winnipeg, MB R3E 3P6
来源：
Current HIV/AIDS Reports | 2010年 / 7卷 / 2期
关键词：
Biomarkers; HIV resistance; HIV/AIDS; Mucosal immunology; Proteomics; Systems biology; Transcriptomics;
D O I：
10.1007/s11904-010-0039-3
中图分类号：
学科分类号：
摘要：
Worldwide HIV infects women more frequently than men, and it is clear that not all exposed to HIV become infected. Several populations of HIV-exposed uninfected (EU) women have been identified, including discordant couples and sex workers. Understanding what provides natural protection in EU women is critical in vaccine or microbicide development. However, correlates of protection in these women are still unclear. Most studies have used classical methods, examining single genes or cellular factors, a mainstay for traditional immunobiology. This reductionist approach may be limited in the information it can provide. Novel technologies are now available that allow us to take a "systems biology" approach, which allows the study of a complex biological system and identifies factors that may provide protection against HIV infection. Herein we report developments in discovery-based systems biology approaches in EU women and how this broadens our understanding of natural protection against HIV-1. © Springer Science+Business Media, LLC 2010.
引用
收藏
页码：53 / 59
页数：6
相关论文
共 52 条
  • [1] UNAIDS: Report on the Global AIDS Epidemic, (2008)
  • [2] Quinn T.C., Overbaugh J., HIV/AIDS in women: An expanding epidemic, Science, 308, pp. 1582-1583, (2005)
  • [3] Shattock R.J., Moore J.P., Inhibiting sexual transmission of HIV-1 infection, Nat Rev Microbiol, 1, pp. 25-34, (2003)
  • [4] Samson M., Libert F., Doranz B.J., Et al., Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene, Nature, 382, pp. 722-725, (1996)
  • [5] Stranford S.A., Skurnick J., Louria D., Et al., Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response, Proc Natl Acad Sci U S A, 96, pp. 1030-1035, (1999)
  • [6] Boulet S., Sharafi S., Simic N., Et al., Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals, AIDS, 22, pp. 595-599, (2008)
  • [7] Ball T.B., Ji H., Kimani J., Et al., Polymorphisms in IRF-1 associated with resistance to HIV-1 infection in highly exposed uninfected Kenyan sex worker, AIDS, 21, pp. 1091-1101, (2007)
  • [8] Wichukchinda N., Kitamura Y., Rojanawiwat A., Et al., The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection, AIDS Res Hum Retroviruses, 23, pp. 686-692, (2007)
  • [9] Miyazawa M., Lopalco L., Mazzotta F., Et al., The "immunologic advantage" of HIV-exposed seronegative individuals, AIDS, 23, pp. 161-175, (2009)
  • [10] Iqbal S.M., Ball T.B., Kimani J., Et al., Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers, J Infect Dis, 192, pp. 728-738, (2005)
123456