Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats

被引：0
作者：
Mayada R. Farag
R. M. Abd EL-Aziz
H. A. Ali
Sahar A. Ahmed
机构：
[1] Zagazig University,Department of Forensic Medicine and Toxicology
[2] Zagazig University,Department of Physiology
[3] Zagazig University,Department of Biochemistry, Faculty of Veterinary Medicine
[4] Zagazig University,Department of Forensic Medicine and clinical Toxicology, Faculty of Medicine
来源：
Environmental Science and Pollution Research | 2016年 / 23卷
关键词：
Cadmium; Spermatogenesis; Steroidogenesis; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study was conducted to evaluate the ameliorative efficacy of Spirulina platensis (SP) on reproductive dysfunctions induced by cadmium chloride (CdCl2) in male rats. Rats (n = 40) were divided into five groups (eight rats/each). Group 1: served as control without any treatment. Group 2: Rats were administered SP (150 mg/kg body weight (BW)) in drinking water for 10 days. Group3: Rats were subcutaneously injected with CdCl2 (2 mg/kg BW) daily for 10 days. Group 4: Rats were co-treated with both CdCl2 (2 mg/kg BW) and SP (150 mg/kg BW) daily for 10 days (SP prophylactic group). Group5: Rats received CdCl2 for 10 days followed by administration of SP alone in drinking water daily for another 30 days with the same mentioned routes and doses (SP treatment group). From our findings, the administration of SP alone or co-administration with Cd significantly attenuated the harmful effects of Cd, suggesting its beneficial role in improving spermatogenesis and steroidogenesis after Cd exposure.
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页码：2454 / 2466
页数：12
相关论文
共 278 条
[11]  
Gimenez MS(2002)Supercritical fluid extraction for liquid chromatographic determination of carotenoids in spirulina algae: a chemometric approach Arch Latinoam Nutr 52 232-240
[12]  
Babadzhanov AS(1995)Update on the pharmacology of Spirulina (Arthrospira), an unconventional food Proc Soc Exp Biol Med 210 93-101
[13]  
Abdusamatova N(2013)Nitric oxide: a novel mediator of inflammation Br J Med Med Res 3 2031-2041
[14]  
Yusupova FM(2000)Changes in some testicular biometric parameters and testicular function in cadmium chloride administered Wistar rats Biochem Mol Toxicol 14 238-243
[15]  
Faizullaeva N(2009)Role of beta-carotene in ameliorating the cadmium-induced oxidative stress in rat brain and testis Int J Morphol 27 757-764
[16]  
Mezhlumyan GL(2002)Altered testicular morphology and oxidative stress induced by cadmium in experimental rats and protective effect of simultaneous green tea extract J Food Sci 67 2589-2595
[17]  
Malikova MKH(2010)Antioxidant and antimutagenic activity of dietary chlorophyll derivatives determined by radical scavenging and bacterial reverse mutagenesis assays Arch Appl Sci Res 2 390-397
[18]  
Banjia D(1993)Protective effect of Spirulina platensis on cadmium induced renaltoxicity in wistar rats Int J Vitam Nutr Res 63 93-121
[19]  
Otilia JF(2005)Anticarcinogenic effect of common carotenoids Chemosphere 58 125-130
[20]  
Banjia N(2003)Lead biosorption and desorption by intact and pretreated Spirulina maxima biomass Toxicology 183 57-63
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