Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats

被引：0
作者：
Mayada R. Farag
R. M. Abd EL-Aziz
H. A. Ali
Sahar A. Ahmed
机构：
[1] Zagazig University,Department of Forensic Medicine and Toxicology
[2] Zagazig University,Department of Physiology
[3] Zagazig University,Department of Biochemistry, Faculty of Veterinary Medicine
[4] Zagazig University,Department of Forensic Medicine and clinical Toxicology, Faculty of Medicine
来源：
Environmental Science and Pollution Research | 2016年 / 23卷
关键词：
Cadmium; Spermatogenesis; Steroidogenesis; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study was conducted to evaluate the ameliorative efficacy of Spirulina platensis (SP) on reproductive dysfunctions induced by cadmium chloride (CdCl2) in male rats. Rats (n = 40) were divided into five groups (eight rats/each). Group 1: served as control without any treatment. Group 2: Rats were administered SP (150 mg/kg body weight (BW)) in drinking water for 10 days. Group3: Rats were subcutaneously injected with CdCl2 (2 mg/kg BW) daily for 10 days. Group 4: Rats were co-treated with both CdCl2 (2 mg/kg BW) and SP (150 mg/kg BW) daily for 10 days (SP prophylactic group). Group5: Rats received CdCl2 for 10 days followed by administration of SP alone in drinking water daily for another 30 days with the same mentioned routes and doses (SP treatment group). From our findings, the administration of SP alone or co-administration with Cd significantly attenuated the harmful effects of Cd, suggesting its beneficial role in improving spermatogenesis and steroidogenesis after Cd exposure.
引用
收藏
页码：2454 / 2466
页数：12
相关论文
共 278 条
[1]  
Adamkovičová M(2010)Diazinon and cadmium acute testicular toxicity in rats examined by histopathological and morphometrical methods Slovak J Anim Sci 43 134-140
[2]  
Toman R(2002)Role of oxidants in male infertility: rational, significance, and treatment Urol Clin N Am 29 817-827
[3]  
Cabaj M(2004)Morphological changes and oxidative stress in rat prostate exposed to a non-carcinogenic dose of cadmium Toxicol Lett 153 365-376
[4]  
Agrawal M(2004)Chemical composition of spirulina platensis cultivated in Uzbekistan Chem Nat Compd 40 276-279
[5]  
Saleh RA(2013)Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride Food Chem 140 321-331
[6]  
Alvarez SM(2008)Iron-chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Food Chem 110 436-445
[7]  
Gomez NN(2001)Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Biochem Biophys Res Commun 285 262-266
[8]  
Scardapane L(2000): Protection against oxidative damage to DNA Biochem Biophys Res Commun 275 20-25
[9]  
Zirulnik F(2001)C-phycocyanin a potent peroxyl radical scavenger in vivo and in vitro Reprod Toxicol 15 699-704
[10]  
Martinez D(2001)Effect of ethanol on cadmium-induced testicular toxicity in male rats J Chromatogr 912 61-71
12345678910