Adipokine update - New molecules, new functions

被引：16
作者：
Gelsinger C. [1 ]
Tschoner A. [1 ]
Kaser S. [1 ]
Ebenbichler C.F. [1 ]
机构：
[1] Universitätsklinik für Innere Medizin I, Department Innere Medizin, Medizinische Universität Innsbruck, 6020 Innsbruck Österreich
来源：
Wiener Medizinische Wochenschrift | 2010年 / 160卷 / 15-16期
关键词：
Adipokines; Diabetes; Inflammatory disease; Insulin resistance; Metabolic syndrome; Obesity; Visceral adipose tissue;
D O I：
10.1007/s10354-010-0781-6
中图分类号：
学科分类号：
摘要：
The prevalence of obesity is rising worldwide. Recent research findings show that adipose tissue is a highly active endocrine organ, which is involved in many physiological processes. These metabolic processes are influenced by products of the adipose tissue, so-called adipokines, which play a crucial role in the pathogenesis of the metabolic syndrome and cardiovascular disease. In addition, the two major fat depots - intraabdominal and subcutaneous - differ in their ability to secrete adipokines. In recent years the importance of the association between intraabdominal fat and the development of insulin resistance, diabetes mellitus type 2 and dyslipidemia was recognized. Therefore, accumulation of visceral adipose tissue contributes due to its ability to secrete a different pattern of adipokines to increased morbidity and mortality. This review aims to characterize novel, newly recognized adipokines and to discuss their roles in the pathogenesis of insulin resistance and atherosclerosis, as well as other metabolic complications. © Springer-Verlag 2010.
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页码：377 / 390
页数：13
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