clc is co-expressed with clf or cntfr in developing mouse muscles

被引：10

作者：

de Bovis B. ^{[1
]}

Derouet D. ^{[2
]}

Gauchat J.-F. ^{[3
]}

Elson G. ^{[4
]}

Gascan H. ^{[2
]}

deLapeyrière O. ^{[1
]}

机构：

[1] INSERM UMR 623, Development Biology Institute of Marseille (CNRS - INSERM - Univ. Méditerranée), 13288 Marseille Cedex 09, Campus de Luminy

[2] INSERM U564, CHU d'Angers, 49033 Angers Cedex

[3] Département de Pharmacologie, Université de Montreal, Montréal, QC H3T 1J4

[4] NovImmune SA

来源：

Cell Communication and Signaling | / 3卷 / 1期

关键词：

Ciliary Neurotrophic Factor; Dental Follicle; Motoneuron Loss; Leukaemia Inhibitory Factor Receptor; Molar Tooth Germ;

D O I：

10.1186/1478-811X-3-1

中图分类号：

学科分类号：

摘要：

The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor a component (CNTFR). This tripartite receptor has been shown to play important roles in the development of motor neurons, but the identity of the relevant ligand(s) is still not clearly established. Recently, we have identified two new ligands for the CNTF receptor complex. These are heterodimeric cytokines composed of cardiotrophin-like cytoldne (CLC) associated either with the soluble receptor subunit cytokine-like factor- I (CLF) or the soluble form of the binding receptor itself (sCNTFR). Results: Here we show that, during development, clc is expressed in lung, kidney, vibrissae, tooth, epithelia and muscles during the period of development corresponding to when motoneuron loss is observed in mice lacking a functional CNTF receptor. In addition, we demonstrate that it is co-expressed at the single cell level with df and cntfr, supporting the idea that CLC might be co-secreted with either CLF or sCNTFR. Conclusion: This expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development. © 2005 de Bovis et al; licensee BioMed Central Ltd.

引用

共 15 条

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