Role of Corticotropin-Releasing Factor in Drug AddictionPotential for Pharmacological Intervention

被引:0
作者
Marian L. Logrip
George F. Koob
Eric P. Zorrilla
机构
[1] The Scripps Research Institute,Committee on the Neurobiology of Addictive Disorders
来源
CNS Drugs | 2011年 / 25卷
关键词
CRF1 Receptor; Extended Amygdala; CRF1 Receptor Antagonist; Ventral Tegmental Area Neuronal Activity;
D O I
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中图分类号
学科分类号
摘要
Drug dependence is a chronically relapsing disorder that places an enormous strain on healthcare systems. For treatments to have long-term clinical value, they must address the causes of relapse. Corticotropin-releasing factor (CRF), a neuropeptide central to the stress response, may be one key to solving the relapse cycle. CRF is hypothesized to mediate the elevated anxiety and negative emotional states experienced during the development of dependence. This review summarizes existing data on changes in the CRF system produced by drugs of abuse and the function of CRF receptors in regulating behavioural responses to drugs of abuse, with an emphasis on drug dependence. Drug-induced changes in neuronal excitability throughout the limbic system, as well as the reversal of these neuroadaptations by CRF receptor antagonists, are also addressed. CRF receptor antagonists, by reducing the motivational effects of drug withdrawal and protracted abstinence, are proposed to be novel therapeutic targets for drug abuse and addiction.
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页码:271 / 287
页数:16
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  • [1] Koob GF(2008)A role for brain stress systems in addiction Neuron 59 11-34
  • [2] Sinha R(2008)Chronic stress, drug use, and vulnerability to addiction Ann N Y Acad Sci 1141 105-30
  • [3] Goeders NE(2003)The impact of stress on addiction Eur Neuropsychopharmacol 13 435-41
  • [4] Weiss F(2001)Compulsive drug-seeking behavior and relapse: neuroadaptation, stress, and conditioning factors Ann N Y Acad Sci 937 1-26
  • [5] Ciccocioppo R(2007)Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder Eur Psychiatry 22 282-7
  • [6] Parsons LH(2008)Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP PLoS One 3 e3620-6
  • [7] De Luca V(2009)Gene-environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1 Pharmacol Biochem Behav 93 230-51
  • [8] Tharmalingam S(2008)Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use Biol Psychiatry 63 146-602
  • [9] Kennedy JL(2006)Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples Mol Psychiatry 11 594-21
  • [10] Enoch MA(1981)Primary structure of corticotropin-releasing factor from ovine hypothalamus Proc Natl Acad Sci U S A 78 6517-95