Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis

被引：0
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作者：
Sophie L. M. Walker
Chand Muthoo
Jenifer Sanchez
Ana Gutierrez Del Arroyo
Gareth L. Ackland
机构：
[1] Queen Mary University of London,Translational Medicine and Therapeutics, William Harvey Research Institute
来源：
Intensive Care Medicine Experimental | / 10卷
关键词：
Sepsis; Gender; Leukocyte; Cardiac dysfunction;
D O I：
暂无
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学科分类号：
摘要：
Sex differences in sepsis are underexplored, even though female sex appears to be cardioprotective in early sepsis.In early normovolaemic polymicrobial sepsis, hyperdynamic response occurs in males, whereas myocardial stress/injury is limited in females, in part mediated by less cardiac infiltration of CD4 + leukocytes and independent of shedding of TNFα from peripheral circulating leukocytes.
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