Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis

被引：0
作者：
Sophie L. M. Walker
Chand Muthoo
Jenifer Sanchez
Ana Gutierrez Del Arroyo
Gareth L. Ackland
机构：
[1] Queen Mary University of London,Translational Medicine and Therapeutics, William Harvey Research Institute
来源：
Intensive Care Medicine Experimental | / 10卷
关键词：
Sepsis; Gender; Leukocyte; Cardiac dysfunction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sex differences in sepsis are underexplored, even though female sex appears to be cardioprotective in early sepsis.In early normovolaemic polymicrobial sepsis, hyperdynamic response occurs in males, whereas myocardial stress/injury is limited in females, in part mediated by less cardiac infiltration of CD4 + leukocytes and independent of shedding of TNFα from peripheral circulating leukocytes.
引用
收藏
相关论文
共 481 条
  • [1] Jawa RS(2017)Sepsis in the critically Ill-does gender matter? Crit Care Med 45 1957-1959
  • [2] Kew RR(2014)Gender differences in sepsis: cardiovascular and immunological aspects Virulence 5 12-19
  • [3] Angele MK(2016)Distinct myocardial mechanisms underlie cardiac dysfunction in endotoxemic male and female mice Shock 46 713-722
  • [4] Pratschke S(2014)Gender-specific differences in the in situ cardiac function of endotoxemic rats detected by pressure-volume catheter Shock 42 415-423
  • [5] Hubbard WJ(2022)Hyperdynamic left ventricular ejection fraction in ICU patients with sepsis Crit Care Med 50 770-779
  • [6] Chaudry IH(2015)Hyperdynamic left ventricular ejection fraction in the intensive care unit Crit Care 19 288-642
  • [7] Hobai IA(2017)Left ventricular systolic dysfunction during septic shock: the role of loading conditions Intensive Care Med 43 633-1590
  • [8] Aziz K(2019)Evaluation and predictors of fluid resuscitation in patients with severe sepsis and septic shock Crit Care Med 47 1582-e691
  • [9] Buys ES(2018)Sex-mediated response to the beta-blocker landiolol in sepsis: an experimental, randomized study Crit Care Med 46 e684-441
  • [10] Brouckaert P(2020)X-linked IRAK1 polymorphism is associated with sex-related differences in polymorphonuclear granulocyte and monocyte activation and response variabilities Shock 53 434-R508
12345678910