Beneficial effects of rituximab therapy for systemic lupus erythematosus

被引：0
作者：
Shina Menon
Pankaj Hari
Arvind Bagga
机构：
[1] All India Institute of Medical Sciences,Division of Pediatric Nephrology, Department of Pediatrics
来源：
The Indian Journal of Pediatrics | 2007年 / 74卷
关键词：
B lymphocytes; Lupus nephritis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We report an 11-yr-old girl with systemic lupus erythematosus (SLE) with recurrent flares of skin and systemic manifestations, which were poorly controlled with conventional therapy. Treatment with rituximab, a monoclonal antibody against CD20, was associated with remission of symptoms and a steroid sparing effect that persisted for more than 9 months. Therapy with rituximab appears promising in subjects with SLE.
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页码：79 / 82
页数：3
相关论文
共 58 条
[1]  
Ardoin S.P.(2005)The management of pediatric systemic lupus erythematosus Nature Clin Prac Rheum 1 82-92
[2]  
Schanberg L.E.(1992)Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE Arthritis Rheum 35 630-640
[3]  
Bombardier C.(2006)Drug insight: rituxumab in renal disease and transplantation Nature Clin Prac Nephrol 2 221-230
[4]  
Gladman D.D.(2006)Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis Arthritis Rheum 54 613-620
[5]  
Urowitz M.B.(2001)Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity Nature Immunol 2 764-766
[6]  
Caron D.(2005)Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases Ann Rheum Dis 64 913-920
[7]  
Chang C.H.(2005)B cell depletion in the treatment of patients with systemic lupus erythematosus: A longitudinal analysis of 24 patients Rheumatology (Oxford) 44 1542-1545
[8]  
Salama A.D.(2004)B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab Arthritis Rheum 50 2580-2589
[9]  
Pusey C.D.(2002)Anti-CD20 monoclonal antibody (rituximab) for life-threatening autoimmune hemolytic anemia in a patient with systemic lupus erythematosus Br J Hematol 116 465-467
[10]  
Leandro M.J.(2004)Anti-CD20 monoclonal antibody (rituximab) for refractory autoimmune thrombocytopenia in a girl with systemic lupus erythematosus Rheumatology (Oxford) 43 244-813
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