In vivo selection of tumor-targeting RNA motifs

被引：0

作者：

Mi J. ^{[1
]}

Liu Y. ^{[1
]}

Rabbani Z.N. ^{[2
]}

Yang Z. ^{[3
]}

Urban J.H. ^{[1
]}

Sullenger B.A. ^{[1
]}

Clary B.M. ^{[1
]}

机构：

[1] Department of Surgery, Duke University Medical Center, Durham, NC

[2] Department of Rradiation Oncology, Duke University Medical Center, Durham, NC

[3] Department of Internal Medicine, Moses Cone Memorial Hospital, Greensboro, NC

来源：

Nature Chemical Biology | 2010年 / 6卷 / 1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nchembio.277

中图分类号：

学科分类号：

摘要：

In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer. © 2010 Nature America, Inc. All rights reserved.

引用

页码：22 / 24

页数：2

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