Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

The solvothermal method synthesized magnetite (Fe3O4) and investigated the processes of immobilization of the cytostatic drug doxorubicin (DOX) on its surface in the medium of 0.9% NaCl solution. The size and morphology (transmission electron microscopy (TEM), crystalline phase magnetite formation [X-ray diffraction analysis (XRD), FTIR spectroscopy] and magnetic properties (vibration magnetometer (VSM), specific surface area and pore size were determined by the method of nitrogen thermal desorption were investigated for the synthesized samples. The adsorption processes were studied and the high adsorption activity of the Fe3O4 nanoparticles (MNPs) surface with respect to DOX was established in the model physiological environment. According to the studies, the adsorption equilibrium time is 45–90 min with up to 80% DOX extraction and maximum adsorption capacity (Amax) 17.5 mg g−1. The analysis of kinetic dependences and DOX adsorption isotherms using mathematical models that take into account the chemical interaction in the system indicates the monomolecular nature of adsorption (Freundlich model). Obtained MNPs can be potentially suitable for oncology applications specifically in the targeted drug delivery and adsorption materials of intracorporeal and extracorporeal detoxification of the body.