Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring

被引：1
作者：
T. A. Rodina
E. S. Mel’nikov
A. I. Dmitriev
S. A. Belkov
A. V. Sokolov
V. V. Arkhipov
A. B. Prokof’ev
机构：
[1] Scientific Center for Expert Evaluation of Medical Products,
[2] Ministry of Health of the Russian Federation,undefined
[3] I. V. Davydovsky Municipal Clinical Hospital,undefined
[4] Moscow City Department of Health,undefined
[5] 3I. M. Sechenov First Moscow State Medical University,undefined
来源：
Pharmaceutical Chemistry Journal | 2018年 / 51卷
关键词：
metoprolol; bisoprolol; HPLC-MS/MS; arterial hypertension; therapeutic drug monitoring;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.
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页码：1111 / 1118
页数：7
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