Ionic liquids in protein amyloidogenesis: a brief screenshot of the state-of-the-art

被引：37
作者：
Visakh V. S. Pillai
Antonio Benedetto
机构：
[1] University College Dublin,School of Physics
[2] University College Dublin,Conway Institute of Biomolecular and Biomedical Research
[3] University College Dublin,School of Chemistry
[4] Paul Scherrer Institut,Laboratory for Neutron Scattering
来源：
Biophysical Reviews | 2018年 / 10卷 / 3期
关键词：
D O I：
10.1007/s12551-018-0425-4
中图分类号：
学科分类号：
摘要：
Ionic liquids (ILs) are a vast class of organic non-aqueous electrolytes whose interaction with biomolecules is receiving great attention for potential applications in bio-nano-technology. Recently, it has been shown that ILs can affect protein amyloidogenesis. Whereas some ILs favour the aggregation of proteins into amyloids, others inhibit their formation. Moreover, ILs can dissolve mature fibrils and restore the protein biochemical function. In this letter, we present a brief state-of-the-art summary of this emerging field that holds the promise of important developments both in basic science and in applications from bio-medicine to material science, and bio-nano-technology. The huge variety of ILs offers a vast playground for future studies and potential applications.
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收藏
页码：847 / 852
页数：5
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