Reverse remodeling in heart failure—mechanisms and therapeutic opportunities

被引：0
作者：
Norimichi Koitabashi
David A. Kass
机构：
[1] Gunma University Graduate School of Medicine,Department of Medicine and Biological Sciences
[2] Johns Hopkins Medical Institutions,Division of Cardiology, Department of Medicine
来源：
Nature Reviews Cardiology | 2012年 / 9卷
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D O I：
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摘要：
Understanding mechanisms of cardiac remodeling, with the goal of developing therapies to stop or reverse its progression, has become a major objective for investigators of heart failure. In this Review, Dr Koitabashi and Professor Kass discuss the evidence for 'reverse remodeling' by existing therapies, and review novel approaches that are currently moving from preclinical to clinical trials.
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页码：147 / 157
页数：10
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[21]  
Krishnamoorthy A(2011)Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial Science 332 361-365
[22]  
Mudd JO(2011)Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca J. Biomed. Biotechnol. 2011 141039-3419
[23]  
Kass DA(2005)-dependent signaling Circulation 111 3411-435
[24]  
Kass DA(2001)Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism J. Am. Coll. Cardiol. 38 429-2206
[25]  
Klotz S(2004)Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure J. Am. Coll. Cardiol. 43 2200-557
[26]  
Dipla K(2004)Changes in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction Circulation 110 552-820
[27]  
Mattiello JA(1994)Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated cardiomyopathy J. Mol. Cell Cardiol. 26 809-16
[28]  
Jeevanandam V(2005)Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the Heart Outcomes Prevention Evaluation (HOPE) Trial Congest. Heart Fail. 11 12-1673
[29]  
Houser SR(2003)Different effects of antihypertensive therapies based on losartan or atenolol on ultrasound and biochemical markers of myocardial fibrosis: results of a randomized trial J. Am. Coll. Cardiol. 42 1666-920
[30]  
Margulies KB(2005)Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone Hypertension 45 914-2565
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