Relationship between physicochemical properties, lipophilicity parameters, and local anesthetic activity of dibasic esters of phenylcarbamic acid

被引：0
|
作者：
I. Malík
E. Sedlárová
J. Csöllei
F. Andriamainty
J. Čižmárik
机构：
[1] Comenius University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[2] University of Veterinary and Pharmaceutical Sciences,Institute of Chemical Drugs, Faculty of Pharmacy
来源：
Chemical Papers | 2007年 / 61卷
关键词：
phenylcarbamates; acidity; lipophilicity; local anesthesia; QSAR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The basic physicochemical properties, lipophilicity parameters of dibasic alkyloxy-substituted phenylcarbamic acids were estimated. For the prepared set of compounds the experimentally obtained solubility, acidity, and lipophilicity parameters were correlated with those computed using various computer programs based on the associative artificial neural network and fragmental methods. The results of pharmacological evaluation were used as entry data for the complex correlations.
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页码：206 / 213
页数：7
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