Influence of Melatonin-Correcting Drugs (Melaxen and Valdoxan) on the Levels of Superoxide Dismutase and Catalase Gene Transcription in Rats with Experimental Hyperthyroidism
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作者:
T. N. Popova
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机构:Voronezh State University,
T. N. Popova
A. A. Agarkov
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机构:Voronezh State University,
A. A. Agarkov
M. V. Gorbenko
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机构:Voronezh State University,
M. V. Gorbenko
S. S. Popov
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机构:Voronezh State University,
S. S. Popov
K. K. Shul’gin
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机构:Voronezh State University,
K. K. Shul’gin
机构:
[1] Voronezh State University,
[2] N. N. Burdenko Voronezh State Medical Academy,undefined
The influence of the melatonin-correcting drugs melaxen and Valdoxan on the gene-transcription level of superoxide dismutase (SOD, EC 1.15.1.1) and catalase (EC 1.11.1.6) in liver and heart of rats with hyperthyroidism has been investigated. Administration of these drugs to rats with model pathology leads to changes in SOD and catalase expression in their tissues toward the control values.