Multi-organ damage induced by anabolic steroid supplements: A case report and literature review

被引:11
作者
Samaha A.A. [1 ,2 ,3 ,4 ,5 ,6 ]
Nasser-Eddine W. [1 ]
Shatila E. [1 ]
Haddad J.J. [3 ]
Wazne J. [1 ]
Eid A.H. [7 ]
机构
[1] Department of Internal Medicine, Makassed General Hospital, Beirut
[2] Department of Human Morphology, Faculty of Public Health, Lebanese University, Zahle
[3] Cellular and Molecular Signaling Research Group, Department of Biology, Lebanese International University, Beirut
[4] Department of Nutrition and Dietetic, Faculty of Arts and Sciences, Lebanese International University, Beirut
[5] Clinical Laboratory, Faculty of Public Health, Lebanese University, Zahle
[6] Lebanese School of Social Formation, Community Health Program, Saint-Joseph University, Beirut
[7] Department of Biology, College of Science, United Arab Emirates University, Al-Ain
关键词
Testosterone; Acute Pancreatitis; Hypercalcemia; Anabolic Steroid; Amino Acid Supplement;
D O I
10.1186/1752-1947-2-340
中图分类号
学科分类号
摘要
Introduction: The use of anabolic supplements and other related drugs for body building and to enhance athletic performance is nowadays widespread and acutely pervasive all around the world. This alarming increase in the use of anabolic and amino acid supplements has been linked to a diverse array of pathologies. As previously reported, the abuse of androgenic steroids is not without severe physiological, psychiatric and physical costs. The case we report here describes multi-organ damage resulting from the abuse and uncontrolled use of anabolic steroid supplements, mainly testosterone. Case presentation: A 24-year-old white man presented with abdominal pain concomitant with nausea and vomiting. Laboratory analysis revealed hypercalcemia, elevated liver enzymes and high levels of amylase, lipase and creatine protein kinase. Conclusion: Amino acid as well as anabolic supplements may lead to abnormal functioning of many organs, which could be fatal in some instances. This mandates worldwide and concerted efforts to educate the public, especially the youth, about the dangers of these increasingly abused drugs. © 2008 Samaha et al; licensee BioMed Central Ltd.
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共 15 条
[1]  
Pope Jr. H.G., Brower K.J., Anabolic-androgenic steroid abuse, Comprehensive Textbook of Psychiatry/VII, pp. 1085-1095, (2000)
[2]  
Bonetti A., Tirelli F., Catapano A., Dazzi D., Dei Cas A., Solito F., Ceda G., Reverberi C., Monica C., Pipitone S., Elia G., Spattini M., Magnati G., Side effects of anabolic androgenic steroids abuse, Int J Sports Med, 29, 8, pp. 679-687, (2008)
[3]  
Malone Jr. D.A., Dimeff R.J., The use of fluoxetine in depression associated with anabolic steroid withdrawal: A case series, J Clin Psychiatry, 53, pp. 130-132, (1992)
[4]  
Gruber A.J., Pope Jr. H.G., Psychiatric and medical effects of anabolic-androgenic steroid use in women, Psychother Psychosom, 69, pp. 19-26, (2000)
[5]  
Goldfarb S., Agus Z.S., Mechanism of the polyuria of hypercalcemia, Am J Nephrol, 4, 2, pp. 69-76, (1984)
[6]  
Dembinski A., Warzecha Z., Ceranowicz P., Bielanski W., Cieszkowski J., Dembinski M., Pawlik W.W., Kuwahara A., Kato I., Konturek P.C., Variable effect of ghrelin administration on pancreatic development in young rats. Role of insulin-like growth factor-1, J Physiol Pharmacol, 56, 4, pp. 555-570, (2005)
[7]  
Norman A.W., Intestinal calcium absorption: A vitamin D-hormone-mediated adaptive response, Am J Clin Nutr, 51, 2, pp. 290-300, (1990)
[8]  
Henry H.L., Norman A.W., Vitamin D: Metabolism and biological actions, Annu Rev Nutr, 4, pp. 493-520, (1984)
[9]  
Cashman K.D., Calcium and vitamin D, Novartis Found Symp, 282, pp. 123-138, (2007)
[10]  
Talih F., Fattal O., Malone Jr. D., Anabolic steroid abuse: Psychiatric and physical costs, Cleve Clin J Med, 74, 5, pp. 341-344, (2007)