Synthesis and fungicidal activity of substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols

被引：0
作者：
S. V. Popkov
A. A. Makarenko
G. I. Nikishin
机构：
[1] D. I. Mendeleev University of Chemical Technology of Russia,N. D. Zelinsky Institute of Organic Chemistry
[2] Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2016年 / 65卷
关键词：
6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols; imidazole; spiro[4.5]-decan-6-one; triadimenol; 1,2,4-triazole; fungicidal activity;
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学科分类号：
摘要：
A series of halogen substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols were obtained from spiro[4.5]decan-6-one in three steps: Claisen—Schmidt condensation with substituted benzaldehydes, conversion of 7-benzylidenespiro[4.5]decan-6-ones to oxiranes by reaction with dimethylsulphonium methylide followed by ring opening of oxiranes with 1,2,4-triazole or imidazole. In vitro testing of fungicidal activity of synthesized compounds against seven phytopathogenic fungi showed, that a number of compounds are more active than triadimenol.
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页码：513 / 518
页数：5
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