New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway

被引:0
|
作者
Kang Chen
Bi-zhu Chu
Feng Liu
Bin Li
Chun-mei Gao
Lu-lu Li
Qin-sheng Sun
Zhi-fa Shen
Yu-yang Jiang
机构
[1] Tsinghua University,Department of Chemistry
[2] The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology,undefined
[3] Graduate School at Shenzhen,undefined
[4] Tsinghua University,undefined
[5] Shenzhen Anti-Tumor Drug Development Engineering Laboratory,undefined
[6] Graduate School at Shenzhen,undefined
[7] Tsinghua University,undefined
[8] Shenzhen Kivita Innovative Drug Discovery Institute,undefined
[9] School of Medicine,undefined
[10] Tsinghua University,undefined
来源
Acta Pharmacologica Sinica | 2015年 / 36卷
关键词
benzimidazole acridine; anticancer drug; colon cancer; apoptosis; death receptor-5; JNK1; ROS;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1074 / 1084
页数:10
相关论文
共 50 条
  • [21] A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway
    Hai-jun Wang
    Yu Liu
    Li-qiao Fan
    Cai-li Han
    Ye Jiang
    Shu-jie Cheng
    Yong Li
    Acta Pharmacologica Sinica, 2013, 34 : 1535 - 1544
  • [22] Phloroglucinol Derivative MCPP Induces Cell Apoptosis in Human Colon Cancer
    Huang, Ssu-Ming
    Cheung, Chi-Wai
    Chang, Chih-Shiang
    Tang, Chih-Hsin
    Liu, Ju-Fang
    Lin, Yu-Hsin
    Chen, Jia-Hong
    Ko, Shihi-Hsun
    Wong, Kar-Lok
    Lu, Dah-Yuu
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (02) : 643 - 652
  • [23] Moscatilin Induces Apoptosis in Human Head and Neck Squamous Cell Carcinoma Cells via JNK Signaling Pathway
    Lee, Eunji
    Han, Ah-Reum
    Nam, Bomi
    Kim, Ye-Ram
    Jin, Chang Hyun
    Kim, Jin-Baek
    Eun, Young-Gyu
    Jung, Chan-Hun
    MOLECULES, 2020, 25 (04):
  • [24] Tinospora sinensis (Lour.) Merr alkaloid rich extract induces colon cancer cell death via ROS mediated, mTOR dependent apoptosis pathway: "an in-vitro study"
    Gari, Sreelakshmi Badavenkatappa
    Nelson, Vinod K. K.
    Peraman, Ramalingam
    BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 23 (01)
  • [25] Tinospora sinensis (Lour.) Merr alkaloid rich extract induces colon cancer cell death via ROS mediated, mTOR dependent apoptosis pathway: “an in-vitro study”
    Sreelakshmi Badavenkatappa gari
    Vinod K. Nelson
    Ramalingam Peraman
    BMC Complementary Medicine and Therapies, 23
  • [26] An Anti-Tumor Peptide from Musca domestica Pupae (MATP) Induces Apoptosis in Human Liver Cancer Cells HepG2 Cells Through a ROS-JNK Pathway
    Cheng, Dai
    Meng, Meng
    Zhang, Xinyu
    Wang, Chunling
    INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2017, 23 (01) : 101 - 109
  • [27] Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway
    Song, Changfeng
    Xu, Wen
    Wu, Hongkun
    Wang, Xiaotong
    Gong, Qianyi
    Liu, Chang
    Liu, Jianwen
    Zhou, Lin
    CELL DEATH & DISEASE, 2020, 11 (10)
  • [28] Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer
    Wang, Lihua
    Wang, Canwei
    Tao, Zheying
    Zhao, Liqian
    Zhu, Zheng
    Wu, Wencan
    He, Ye
    Chen, Hong
    Zheng, Bin
    Huang, Xiangjie
    Yu, Yun
    Yang, Linjun
    Liang, Guang
    Cui, Ri
    Chen, Tongke
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (01)
  • [29] Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion
    Sun, Zhu-Lei
    Dong, Jin-Long
    Wu, Jiang
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 85 : 303 - 312
  • [30] Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
    Liu, Xihong
    Zhao, Peiyuan
    Wang, Xiujuan
    Wang, Lei
    Zhu, Yingjun
    Gao, Wei
    FRONTIERS IN ONCOLOGY, 2019, 9