The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

被引:0
作者
Chander Peddaboina
Daniel Jupiter
Steven Fletcher
Jeremy L Yap
Arun Rai
Richard P Tobin
Weihua Jiang
Philip Rascoe
M Karen Newell Rogers
W Roy Smythe
Xiaobo Cao
机构
[1] The Texas A&M University System,Department of Surgery, Scott & White Memorial Hospital and Clinic
[2] Health Science Center,Department of Pharmaceutical Sciences
[3] College of Medicine,undefined
[4] University of Maryland School of Pharmacy,undefined
[5] Boston University School of Medicine,undefined
来源
BMC Cancer | / 12卷
关键词
Mcl-1; Bcl-xL; USP9X; Ubiquitination; Cancer;
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[1]  
Lebedeva I(2000)Bcl-xl in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity Cancer Res 60 6052-6060
[2]  
Rando R(2008)Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts Int J Cancer 123 202-208
[3]  
Ojwang J(2007)Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing bak activation and bax translocation Cancer Res 67 782-791
[4]  
Cossum P(2006)The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized Cancer Cell 10 389-388
[5]  
Stein CA(2006)Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia Cancer Cell 10 375-3313
[6]  
Littlejohn JE(2010)Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1 Blood 115 3304-795
[7]  
Cao X(2012)Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737 Clin Cancer Res 18 783-83
[8]  
Miller SD(2009)RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway PLoS One 4 e6651-3909
[9]  
Ozvaran MK(2009)Endogenous noxa determines the strong proapoptotic synergism of the BH3-mimetic ABT-737 with chemotherapeutic agents in human melanoma cells Transl Oncol 2 73-31
[10]  
Jupiter D(2001)MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes Blood 97 3902-2216