Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

被引：0

作者：

N. Polkam

S. Malthum

J. S. Anireddy

U. Brahma

G. M. Naidu Vegi

机构：

[1] Jawaharlal Nehru Technological University Hyderabad,Centre for Chemical Sciences and Technology, Institute of Science and Technology

[2] Kukatpally,Department of Pharmacology and Toxicology

[3] National Institute of Pharmaceutical Education and Research,undefined

来源：

Russian Chemical Bulletin | 2021年 / 70卷

关键词：

1,3,4-oxadiazoles; 2,5-dimethoxyphenyl; anticancer agents; MTT assay; thioethers; sulfides;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.

引用

页码：580 / 584

页数：4

共 50 条

[11] Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors
Erensoy, Gizem
Ding, Kai
Zhan, Chang-Guo
Elmezayen, Ammar
Yelekci, Kemal
Duracik, Merve
Ozakpinar, Ozlem Bingol
Kucukguzel, Ilkay
JOURNAL OF RESEARCH IN PHARMACY, 2020, 24 (04): : 436 - 451
[12] 1,3,4-Oxadiazole: A Biologically Active Scaffold
Khalilullah, H.
Ahsan, M. J.
Hedaitullah, Md
Khan, S.
Ahmed, B.
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2012, 12 (08) : 789 - 801
[13] Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety
Zhao, Ji-Jun
Wang, Xue-Feng
Li, Bao-Lin
Zhang, Rui-Lian
Li, Bo
Liu, Yu-Ming
Li, Cai-Wen
Liu, Jin-Biao
Chen, Bao-Quan
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (18) : 4414 - 4416
[14] Synthesis and broad-spectrum antiproliferative activity of diarylamides and diarylureas possessing 1,3,4-oxadiazole derivatives
El-Din, Mahmoud M. Gamal
El-Gamal, Mohammed I.
Abdel-Maksoud, Mohammed S.
Yoo, Kyung Ho
Oh, Chang-Hyun
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (08) : 1692 - 1699
[15] Microwave-assisted synthesis of benzimidazole bearing 1,3,4-oxadiazole derivatives: screening for their in vitro antimicrobial activity
Desai, N. C.
Kotadiya, G. M.
MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (09) : 4021 - 4033
[16] Exploring Therapeutic Potential of 1,3,4-Oxadiazole Nucleus as Anticancer Agents: A Mini-review
Bukhari, Asma
Nadeem, Humaira
Sarwar, Sadia
Abbasi, Inzamam
Khan, Muhammad Tariq
Hamid, Iqra
Bukhari, Uzma
MEDICINAL CHEMISTRY, 2023, 19 (02) : 119 - 131
[17] Microwave-assisted synthesis of benzimidazole bearing 1,3,4-oxadiazole derivatives: screening for their in vitro antimicrobial activity
N. C. Desai
G. M. Kotadiya
Medicinal Chemistry Research, 2014, 23 : 4021 - 4033
[18] Design and Ultrasound Assisted Synthesis of Novel 1,3,4-Oxadiazole Drugs for Anti-Cancer Activity
Bhatt, Priyanka
Sen, Anik
Jha, Anjali
CHEMISTRYSELECT, 2020, 5 (11): : 3347 - 3354
[19] Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents
Rezaei, Zahra
Moghimi, Setareh
Javaheri, Rezvan
Asadi, Mehdi
Mahdavi, Mohammad
Shabani, Shabnam
Edraki, Najmeh
Firuzi, Omidreza
Safavi, Maliheh
Amini, Mohsen
Asadipour, Ali
Zeinalzadeh, Elnaz
Firoozpour, Loghman
Foroumadi, Alireza
LETTERS IN DRUG DESIGN & DISCOVERY, 2017, 14 (10) : 1138 - 1144
[20] Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents
Cevik, Ulviye Acar
Osmaniye, Derya
Levent, Serkan
Saglik, Begum Nurpelin
Cavusoglu, Betul Kaya
Karaduma, Abdullah Burak
Ozkay, Yusuf
Kaplancikli, Zafer Asim
ACTA PHARMACEUTICA, 2020, 70 (04) : 499 - 513

← 1 2 3 4 5 →