Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

被引：0

作者：

N. Polkam

S. Malthum

J. S. Anireddy

U. Brahma

G. M. Naidu Vegi

机构：

[1] Jawaharlal Nehru Technological University Hyderabad,Centre for Chemical Sciences and Technology, Institute of Science and Technology

[2] Kukatpally,Department of Pharmacology and Toxicology

[3] National Institute of Pharmaceutical Education and Research,undefined

来源：

Russian Chemical Bulletin | 2021年 / 70卷

关键词：

1,3,4-oxadiazoles; 2,5-dimethoxyphenyl; anticancer agents; MTT assay; thioethers; sulfides;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.

引用

页码：580 / 584

页数：4

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