MicroRNA roles in beta-catenin pathway

被引：0
作者：
Kai Huang
Jun-Xia Zhang
Lei Han
Yong-Ping You
Tao Jiang
Pei-Yu Pu
Chun-Sheng Kang
机构：
[1] Tianjin Medical University General Hospital,Department of Neurosurgery
[2] Tianjin Neurological Institute,Laboratory of Neuro
[3] Ministry of Education and Tianjin Municipal Government,Oncology
[4] The First Affiliated Hospital of Nanjing Medical University,Key Laboratory of Neurotrauma, Variation and Regeneration
[5] Capital Medical University,Department of Neurosurgery
来源：
Molecular Cancer | / 9卷
关键词：
Promote Tumor Cell Invasion; Complex Transcriptional Activity; Tcf4 Interaction; Complex Target Gene;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.
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