Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel

被引:0
作者
L. Sams
S. Kruger
V. Heinemann
D. Bararia
S. Haebe
S. Alig
M. Haas
D. Zhang
C. B. Westphalen
S. Ormanns
P. Metzger
J. Werner
O. Weigert
M. von Bergwelt-Baildon
F. Rataj
S. Kobold
S. Boeck
机构
[1] Ludwig-Maximilians-University of Munich,Department of Internal Medicine III and Comprehensive Cancer Center, Grosshadern University Hospital
[2] German Cancer Consortium (DKTK),Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Internal Medicine III, Grosshadern University Hospital
[3] Ludwig-Maximilians-University,Institute of Pathology, Faculty of Medicine
[4] Ludwig-Maximilians-University,Center of Integrated Protein Science Munich (CIPS
[5] University Hospital of the Ludwig-Maximilians-University,M) and Division of Clinical Pharmacology
[6] Ludwig-Maximilians-University,Department of General, Visceral and Transplantation Surgery
来源
Clinical and Translational Oncology | 2021年 / 23卷
关键词
FOLFIRINOX; Gemcitabine; Nab-paclitaxel; Pancreatic cancer; Immune checkpoints; Regulatory T cells;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2394 / 2401
页数:7
相关论文
共 29 条
[1]  
Quante AS(2016)Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030 Cancer Med 5 2649-2656
[2]  
Von Hoff DD(2013)Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine N Engl J Med 369 1691-1703
[3]  
Conroy T(2011)FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer N Engl J Med 364 1817-1825
[4]  
Bear AS(2020)Challenges and opportunities for pancreatic cancer immunotherapy Cancer Cell 38 788-802
[5]  
Vonderheide RH(2019)Cytotoxic chemotherapy as an immune stimulus: a molecular perspective on turning up the immunological heat on cancer Front Immunol 10 1654-123
[6]  
O'Hara MH(2010)Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses Br J Cancer 102 115-2837
[7]  
Opzoomer JW(2014)Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics Clin Cancer Res 20 2831-32
[8]  
Liu WM(2014)Immunological off-target effects of standard treatments in gastrointestinal cancers Ann Oncol 25 24-564
[9]  
Hato SV(2012)Regulatory T cells: mechanisms of differentiation and function Annu Rev Immunol 30 531-694
[10]  
Duffy AG(2017)Circulating regulatory T cell subsets predict overall survival of patients with unresectable pancreatic cancer Int J Oncol 51 686-1617