Reporting and evaluating genetic association studies

被引：0

作者：

Stephen P Peters

机构：

[1] Wake Forest University Health Sciences,

[2] Center for Human Genomics,undefined

来源：

Respiratory Research | / 10卷

关键词：

Linkage Disequilibrium; Association Study; Minor Allele Frequency; Population Stratification; Genetic Association Study;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Genetic association studies have become an important part of our scientific landscape. This commentary discusses some basic scientific issues which should be considered when reporting and evaluating such studies including SNP Discovery, Genotyping and Haplotype Analysis; Population Size, Matching of Cases and Controls, and Population Stratification; Phenotype Definition and Multiple Related Phenotypes; Multiple Testing; Replication; Genome-wide Association Studies (GWAS); and the Role of Functional Studies. All of these elements are important in evaluating such studies and should be carefully considered when these studies are conceived and carried out.

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