Next-generation gap

被引：0
作者：
McPherson J.D. [1 ]
机构：
[1] John D. McPherson is at the Ontario Institute for Cancer Research,
[2] Toronto,undefined
[3] Ontario,undefined
[4] Canada.,undefined
来源：
Nature Methods | 2009年 / 6卷 / Suppl 11期
关键词：
D O I：
10.1038/nmeth.f.268
中图分类号：
学科分类号：
摘要：
There is a growing gap between the generation of massively parallel sequencing output and the ability to process and analyze the resulting data. New users are left to navigate a bewildering maze of base calling, alignment, assembly and analysis tools with often incomplete documentation and no idea how to compare and validate their outputs. Bridging this gap is essential, or the coveted $1,000 genome will come with a $20,000 analysis price tag. © 2009 Macmillan Publishers Limited. All rights reserved.
引用
收藏
页码：S2 / S5
相关论文
共 30 条
  • [1] Sanger F., Nicklen S., Coulson A.R., Proc. Natl. Acad. Sci. USA, 74, pp. 5463-5467, (1977)
  • [2] Smith L.M., Et al., Nature, 321, pp. 674-679, (1986)
  • [3] McPherson J.D., Et al., Nature, 409, pp. 934-941, (2001)
  • [4] Lander E.S., Et al., Nature, 409, pp. 860-921, (2001)
  • [5] Kent W.J., Haussler D., Genome Res, 11, pp. 1541-1548, (2001)
  • [6] Myers E.W., Et al., Science, 287, pp. 2196-2104, (2000)
  • [7] Huson D.H., Et al., Bioinformatics, 17, 1, pp. S132-S139, (2001)
  • [8] Venter J.C., Et al., Science, 291, pp. 1304-1351, (2001)
  • [9] Kent W.J., Et al., Genome Res, 12, pp. 996-1006, (2002)
  • [10] Hubbard T., Et al., Nucleic Acids Res, 30, pp. 38-41, (2002)
123