Thrombopoietin Signaling Pathway Regulates Hepatocyte Activation in Rat Liver Regeneration

被引：0
作者：
Cuifang Chang
Jing Yang
Xiaofang Li
Weiming Zhao
Yu Li
Pengjuan Guo
Gaiping Wang
Cunshuan Xu
机构：
[1] Henan Normal University,College of Life Science
[2] Henan Normal University,State Key Laboratory Cultivation Base for Cell Differentiation Regulation
来源：
Biochemical Genetics | 2015年 / 53卷
关键词：
Hepatocytes activation; Liver regeneration; THPO signaling pathway; Rat Genome 230 2.0 Array; Gene expression profile;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Thrombopoietin (THPO) signaling pathway regulates cell activation and many other physiological activities. To study its role in liver regeneration (LR), hepatocytes were isolated from rat regenerating livers and gene expression profile was detected using the Rat Genome 230 2.0 Array. Spectral function (Et) and information correlation coefficient (ICC) were used to analyze gene synergy based on gene expression changes. The results showed that 35 genes related to THPO signaling pathway were significantly changed during rat LR. Functional analysis with ICC showed that five genes, STAT3, PLSCR1, CTGF, PRLR, and LCP1, played a key role in hepatocyte activation. Fourteen channels of THPO signaling pathway participated in regulating hepatocyte activation during rat LR.
引用
收藏
页码：244 / 259
页数：15
相关论文
共 203 条
[11]  
Stephan DA(2014)Thrombopoietin from beginning to end Blood 165 259-268
[12]  
Jusko WJ(2005)Thrombopoietin (TPO) Nihon Rinsho 63 618-620
[13]  
Chalmers JJ(1998)Thrombopoietin and the hematopoietic stem cell J Am Soc Hematol 92 1-3
[14]  
Zborowski M(2001)Liver regeneration after hepatectomy Hepato-gastroenterology 48 556-562
[15]  
Sun L(1996)Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice Blood 87 4544-S356
[16]  
Moore L(2009)New thrombopoietic growth factors Clin Lymphoma Myeloma 9 S347-195
[17]  
Chen X(2004)The effect of Korean red ginseng on liver regeneration after 70% hepatectomy in rats Vet Med Sci 66 193-1047
[18]  
Xu C(2008)RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production J Gene Med 10 1039-200
[19]  
Zhang F(2014)Study on the activity of the signaling pathways regulating hepatocytes from G0 phase into G1 phase during rat liver regeneration Cell Mol Biol Lett 19 181-896
[20]  
Ma J(2006)Studying phenotypic evolution using multivariate quantitative genetics Mol Ecol 15 883-3193
12345678910