Thrombopoietin Signaling Pathway Regulates Hepatocyte Activation in Rat Liver Regeneration

被引：0
作者：
Cuifang Chang
Jing Yang
Xiaofang Li
Weiming Zhao
Yu Li
Pengjuan Guo
Gaiping Wang
Cunshuan Xu
机构：
[1] Henan Normal University,College of Life Science
[2] Henan Normal University,State Key Laboratory Cultivation Base for Cell Differentiation Regulation
来源：
Biochemical Genetics | 2015年 / 53卷
关键词：
Hepatocytes activation; Liver regeneration; THPO signaling pathway; Rat Genome 230 2.0 Array; Gene expression profile;
D O I：
暂无
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学科分类号：
摘要：
Thrombopoietin (THPO) signaling pathway regulates cell activation and many other physiological activities. To study its role in liver regeneration (LR), hepatocytes were isolated from rat regenerating livers and gene expression profile was detected using the Rat Genome 230 2.0 Array. Spectral function (Et) and information correlation coefficient (ICC) were used to analyze gene synergy based on gene expression changes. The results showed that 35 genes related to THPO signaling pathway were significantly changed during rat LR. Functional analysis with ICC showed that five genes, STAT3, PLSCR1, CTGF, PRLR, and LCP1, played a key role in hepatocyte activation. Fourteen channels of THPO signaling pathway participated in regulating hepatocyte activation during rat LR.
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页码：244 / 259
页数：15
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