Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample

被引:0
|
作者
Regina Silva Paradela
Alberto Fernando Oliveira Justo
Vítor Ribeiro Paes
Renata E. P. Leite
Carlos A. Pasqualucci
Lea T. Grinberg
Michel Satya Naslavsky
Mayana Zatz
Ricardo Nitrini
Wilson Jacob-Filho
Claudia Kimie Suemoto
机构
[1] University of São Paulo Medical School,Division of Geriatrics
[2] University of Sao Paulo Medical School,Department of Pathology
[3] University of California,Memory and Aging Center
[4] University of São Paulo,Human Genome and Stem Cell Center, Biosciences Institute
[5] University of São Paulo Medical School,Department of Neurology
来源
Acta Neuropathologica Communications | / 11卷
关键词
Apolipoprotein E; Cognition; Dementia; Neuritic plaques; Neurofibrillary tangles; Mediation analysis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 48 条
  • [1] Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample
    Paradela, Regina Silva
    Justo, Alberto Fernando Oliveira
    Paes, Vitor Ribeiro
    Leite, Renata E. P.
    Pasqualucci, Carlos A.
    Grinberg, Lea T.
    Naslavsky, Michel Satya
    Zatz, Mayana
    Nitrini, Ricardo
    Jacob-Filho, Wilson
    Suemoto, Claudia Kimie
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2023, 11 (01)
  • [2] Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease
    Achouri-Rassas, Afef
    Ben Ali, Nadia
    Cherif, Aroua
    Fray, Saloua
    Siala, Hajer
    Zakraoui, Nouria Oudiaa
    Hadj-Fredj, Sondes
    Kechaou, Mariem
    Anane, Nadia
    Echebi, Slim
    Messaoud, Taieb
    Belal, Samir
    JOURNAL OF NEURAL TRANSMISSION, 2016, 123 (03) : 317 - 321
  • [3] Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease
    Afef Achouri-Rassas
    Nadia Ben Ali
    Aroua Cherif
    Saloua Fray
    Hajer Siala
    Nouria Oudiaa Zakraoui
    Sondes Hadj-Fredj
    Mariem Kechaou
    Nadia Anane
    Slim Echebi
    Taieb Messaoud
    Samir Belal
    Journal of Neural Transmission, 2016, 123 : 317 - 321
  • [4] Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants
    Prokopenko, Inga
    Miyakawa, Gentaro
    Zheng, Bang
    Heikkinen, Jani
    Quayle, Daniela Petrova
    Udeh-Momoh, Chinedu
    Claringbould, Annique
    Neumann, Juliane
    Haytural, Hazal
    Kaakinen, Marika A.
    Loizidou, Elena
    Meissner, Esther
    Bertram, Lars
    Gveric, Djordje O.
    Gentleman, Steve M.
    Attems, Johannes
    Perneczky, Robert
    Arzberger, Thomas
    Muglia, Pierandrea
    Lill, Christina M.
    Parkkinen, Laura
    Middleton, Lefkos T.
    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2019, 5 (01) : 814 - 824
  • [5] Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds
    Fatima, Tahzeeb
    Jacobsson, Lennart T. H.
    Kern, Silke
    Zettergren, Anna
    Blennow, Kaj
    Zetterberg, Henrik
    Johansson, Lena
    Dehlin, Mats
    Skoog, Ingmar
    ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2021, 13 (01)
  • [6] Cognitive function in early Parkinson's disease: a population-based study
    Elgh, E.
    Domellof, M.
    Linder, J.
    Edstrom, M.
    Stenlund, H.
    Forsgren, L.
    EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 (12) : 1278 - 1284
  • [7] APOE and AβPP Gene Variation in Cortical and Cerebrovascular Amyloid-β Pathology and Alzheimer's Disease: A Population-Based Analysis
    Peuralinna, Terhi
    Tanskanen, Maarit
    Makela, Mira
    Polvikoski, Tuomo
    Paetau, Anders
    Kalimo, Hannu
    Sulkava, Raimo
    Hardy, John
    Lai, Shiao-Lin
    Arepalli, Sampath
    Hernandez, Dena
    Traynor, Bryan J.
    Singleton, Andrew
    Tienari, Pentti J.
    Myllykangas, Liisa
    JOURNAL OF ALZHEIMERS DISEASE, 2011, 26 (02) : 377 - 385
  • [8] Impact of the Apolipoprotein E ε4 Allele on the Relationship Between Healthy Lifestyle and Cognitive Decline: A Population-Based Study
    Dhana, Klodian
    Aggarwal, Neelum T.
    Rajan, Kumar B.
    Barnes, Lisa L.
    Evans, Denis A.
    Morris, Martha C.
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2021, 190 (07) : 1225 - 1233
  • [9] Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China
    Gu, Cuiying
    Ma, Mingfeng
    Xu, Jiahui
    Yuan, Wei
    Li, Ruixue
    Guo, Hui
    Gao, Hanshu
    Feng, Wenjing
    Guo, Haiqiang
    Zheng, Liqiang
    Zhang, Yao
    FRONTIERS IN PUBLIC HEALTH, 2022, 10
  • [10] Nonlinear association between pulse wave velocity and cognitive function: a population-based study
    Nilsson, Erik D.
    Elmstahl, Solve
    Minthon, Lennart
    Nilsson, Peter M.
    Pihlsgard, Mats
    Tufvesson, Eva
    Nagga, Katarina
    JOURNAL OF HYPERTENSION, 2014, 32 (11) : 2152 - 2157