Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes

被引：0

作者：

Ingrid Brænne

Suna Onengut-Gumuscu

Ruoxi Chen

Ani W. Manichaikul

Stephen S. Rich

Wei-Min Chen

Charles R. Farber

机构：

[1] University of Virginia,Center for Public Health Genomics

[2] University of Virginia,Department of Public Health Sciences

[3] University of Virginia,Department of Biochemistry and Molecular Genetics

[4] University of Colorado,Anschutz Medical Campus, Barbara Davis Center for Childhood Diabetes

[5] University of Turku,Turku University Hospital

[6] Hospital District of Southwest Finland,Center for Biotechnology and Genomic Medicine

[7] Tampere University,Forschergruppe Diabetes E.V. and Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, and Klinikum Rechts Der Isar

[8] Tampere University Hospital,Center for Regenerative Therapies

[9] National Institute for Health and Welfare,Department of Nutritional Epidemiology

[10] University of Oulu,Dr. Von Hauner Children’s Hospital, Department of Gastroenterology

[11] Oulu University Hospital,Bristol Medical School

[12] University of Kuopio,Center for Genetics

[13] Augusta University,undefined

[14] University of Florida,undefined

[15] Pediatric Endocrine Associates,undefined

[16] Technische Universität München,undefined

[17] TU Dresden,undefined

[18] University of Bonn,undefined

[19] Ludwig Maximillians University Munich,undefined

[20] Lund University,undefined

[21] Pacific Northwest Research Institute,undefined

[22] Children’s Hospital of Pittsburgh of UPMC,undefined

[23] University of South Florida,undefined

[24] University of Bristol,undefined

[25] Children’s Hospital Oakland Research Institute,undefined

[26] NIDDK Biosample Repository at Fisher BioServices,undefined

[27] Jinfiniti Biotech,undefined

[28] LLC,undefined

[29] National Institutes of Diabetes and Digestive and Kidney Diseases,undefined

[30] National Institutes of Allergy and Infectious Diseases,undefined

[31] Columbia University,undefined

[32] Florida State University,undefined

来源：

Scientific Reports | / 11卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic and environmental risk factors can both contribute to T1D through dynamic alterations of molecular interactions in physiologic networks. To test this hypothesis, we utilized longitudinal blood transcriptomic profiles in The Environmental Determinants of Diabetes in the Young (TEDDY) study to generate gene co-expression networks. In network modules that contain immune response genes associated with T1D, we observed highly dynamic differences in module connectivity in the 600 days (~ 2 years) preceding clinical diagnosis of T1D. Our results suggest that gene co-expression is highly plastic and that connectivity differences in T1D-associated immune system genes influence the timing and development of clinical disease.

引用

共 50 条

[21] Analysis of co-expression and gene regulatory networks associated with sterile lemma development in rice
Luo, Xi
Wei, Yidong
Zheng, Yanmei
Wei, Linyan
Wu, Fangxi
Cai, Qiuhua
Xie, Huaan
Zhang, Jianfu
BMC PLANT BIOLOGY, 2023, 23 (01)
[22] Analysis of co-expression and gene regulatory networks associated with sterile lemma development in rice
Xi Luo
Yidong Wei
Yanmei Zheng
Linyan Wei
Fangxi Wu
Qiuhua Cai
Huaan Xie
Jianfu Zhang
BMC Plant Biology, 23
[23] Gene Co-Expression Networks Restructured Gene Fusion in Rhabdomyosarcoma Cancers
Helm, Bryan R.
Zhan, Xiaohui
Pandya, Pankita H.
Murray, Mary E.
Pollok, Karen E.
Renbarger, Jamie L.
Ferguson, Michael J.
Han, Zhi
Ni, Dong
Zhang, Jie
Huang, Kun
GENES, 2019, 10 (09)
[24] Gene expression changes in patients with fulminant type 1 diabetes
WANG ZhenZHENG ChaoTAN YuyuLI YijunYANG LinHUANG GanLIN Jian and ZHOU Zhiguang Diabetes CenterSecond Xiangya Hospitaland Institute of Metabolism and EndocrinologyKey Laboratory of Diabetes ImmunologyMinistry of EducationCentral South University ChangshaHunan China
中华医学杂志（英文版）, 2011, (22) : 3613 - 3617
[25] Gene expression changes in patients with fulminant type 1 diabetes
Wang Zhen
Zheng Chao
Tan Yu-yu
Li Yi-jun
Yang Lin
Huang Gan
Lin Jian
Zhou Zhi-guang
CHINESE MEDICAL JOURNAL, 2011, 124 (22) : 3613 - 3617
[26] Analysis of co-expression gene network associated with intracranial aneurysm and type 2 diabetes mellitus
Tian, Tian
Sun, Wenhao
Du, Jia
Sun, Yafei
FRONTIERS IN NEUROLOGY, 2022, 13
[27] Annotation of gene function in citrus using gene expression information and co-expression networks
Wong, Darren C. J.
Sweetman, Crystal
Ford, Christopher M.
BMC PLANT BIOLOGY, 2014, 14
[28] Annotation of gene function in citrus using gene expression information and co-expression networks
Darren CJ Wong
Crystal Sweetman
Christopher M Ford
BMC Plant Biology, 14
[29] Gene-Microbiome Co-expression Networks in Colon Cancer
Uriarte-Navarrete, Irving
Hernandez-Lemus, Enrique
de Anda-Jauregui, Guillermo
FRONTIERS IN GENETICS, 2021, 12
[30] Construction and Analysis of Gene Co-Expression Networks in Escherichia coli
Liu, Wei
Li, Li
Long, Xuhe
You, Weixin
Zhong, Yuexian
Wang, Menglin
Tao, Huan
Lin, Shoukai
He, Huaqin
CELLS, 2018, 7 (03)

← 1 2 3 4 5 →