The Evolution of Single-Cell Analysis and Utility in Drug Development

被引：0

作者：

Shibani Mitra-Kaushik

Anita Mehta-Damani

Jennifer J. Stewart

Cherie Green

Virginia Litwin

Christèle Gonneau

机构：

[1] Sanofi,Bioanalytics

[2] Synthekine,Genomic Medicine Unit

[3] Inc.,Development Sciences

[4] Caprion Biosciences,undefined

[5] Flow Contract Site Laboratory,undefined

[6] Genentech,undefined

[7] Inc.,undefined

[8] A Member of the Roche Group,undefined

[9] Central Laboratory Services,undefined

[10] Labcorp Drug Development,undefined

来源：

The AAPS Journal | / 23卷

关键词：

flow cytometry; drug development; single cell;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vaccines. Moreover, recent technological advances in single-cell analysis are providing more robust cellular measurements and thus accelerating the advancement of novel therapies.

引用

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